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Chemoenzymatic Synthesis of Cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside: A Product of Host Cholesterol Efflux Promoted by Helicobacter pylori
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Aug 02 2012
Source: Chem Commun (Camb). 48(72):9083-9085. -
Alternative Title:Chem Commun (Camb)
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Description:In a three-step protocol involving regioselective enzymatic acylation, per-O-trimethylsilylation, and a one-pot α-glycosidation-deprotection sequence, cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside (α-CAG) of Helicobacter pylori is afforded starting from glucose in an overall yield of 45%. The production of CAG can be scaled to make purified quantities available to the biological community for the first time.
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Pubmed ID:22854787
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Pubmed Central ID:PMC4271795
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