Maternal Residential Atrazine Exposure and Risk for Choanal Atresia and Stenosis in Offspring
Published Date:Oct 01 2012
Source:J Pediatr. 162(3):581-586.
Pubmed Central ID:PMC4105141
Funding:5U01DD000494/DD/NCBDD CDC HHS/United States
L40 DE023736/DE/NIDCR NIH HHS/United States
R03 DE021739/DE/NIDCR NIH HHS/United States
To assess the relationship between estimated residential maternal exposure to atrazine during pregnancy and risk for choanal atresia or stenosis in offspring.
Data for 280 nonsyndromic cases and randomly selected, population-based controls delivered during 1999 to 2008 were obtained from the Texas Birth Defects Registry. County-level estimates of atrazine levels obtained from the United States Geological Survey were assigned to cases and controls based on maternal county of residence at delivery. Unconditional logistic regression was used to assess the relationship between maternal residential atrazine exposure and risk for choanal atresia or stenosis in offspring.
Compared to offspring of mothers with low levels of estimated residential atrazine exposure, those with high levels had nearly a two-fold increase in risk for choanal atresia or stenosis (adjusted odds ratio: 1.79, 95% confidence interval: 1.17–2.74). A significant linear trend was also observed with increasing levels of atrazine exposure (adjusted P = 0.002).
A link between maternal exposure to endocrine disruptors, such as atrazine, and choanal atresia risk is plausible based on previous findings. Our results further support this hypothesis.
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