Maternal Residential Atrazine Exposure and Risk for Choanal Atresia and Stenosis in Offspring

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Agopian, A.J. ; Cai, Yi ; Langlois, Peter H. ; Canfield, Mark A. ; Lupo, Philip J.
• Description:
  Objective
  
  To assess the relationship between estimated residential maternal exposure to atrazine during pregnancy and risk for choanal atresia or stenosis in offspring.
  
  Study Design
  
  Data for 280 nonsyndromic cases and randomly selected, population-based controls delivered during 1999 to 2008 were obtained from the Texas Birth Defects Registry. County-level estimates of atrazine levels obtained from the United States Geological Survey were assigned to cases and controls based on maternal county of residence at delivery. Unconditional logistic regression was used to assess the relationship between maternal residential atrazine exposure and risk for choanal atresia or stenosis in offspring.
  
  Results
  
  Compared to offspring of mothers with low levels of estimated residential atrazine exposure, those with high levels had nearly a two-fold increase in risk for choanal atresia or stenosis (adjusted odds ratio: 1.79, 95% confidence interval: 1.17–2.74). A significant linear trend was also observed with increasing levels of atrazine exposure (adjusted P = 0.002).
  
  Conclusions
  
  A link between maternal exposure to endocrine disruptors, such as atrazine, and choanal atresia risk is plausible based on previous findings. Our results further support this hypothesis.
  
  
• Subjects:
  Adult Article Atrazine Choanal Atresia Constriction, Pathologic Female Herbicides Humans Infant Logistic Models Male Maternal Exposure Pregnancy Risk Factors

  More +
• Source:
  J Pediatr. 162(3):581-586.
• Pubmed ID:
  23036484
• Pubmed Central ID:
  PMC4105141
• Document Type:
  Journal Article
• Funding:
  5U01DD000494/DD/NCBDD CDC HHS/United States ; L40 DE023736/DE/NIDCR NIH HHS/United States ; R03 DE021739/DE/NIDCR NIH HHS/United States
• Place as Subject:
  Texas
• Volume:
  162
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:63bd5c307da02c63bb5cfeeb9e828ccf74e01df037feff104b11756d8dd146ed
• Download URL:
  https://stacks.cdc.gov/view/cdc/33703/cdc_33703_DS1.pdf
• File Type:
  [PDF - 150.37 KB ]