Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN
Published Date:Feb 23 2012
Source:Influenza Other Respi Viruses. 2012; 6(3):e63-e71.
Influenza A Virus, H1N1 Subtype
Pubmed Central ID:PMC3773818
Funding:(U01 IP000184/IP/NCIRD CDC HHS/United States
1K23AI074863-01/AI/NIAID NIH HHS/United States
M01 RR000095/RR/NCRR NIH HHS/United States
U50 ⁄CCU 416123/PHS HHS/United States
In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available.
To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010.
Two separate strategies were applied: capture–recapture and surveillance-sampling methods. For the capture–recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the agespecific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system.
With capture–recapture, we estimated 0.89 (95% CI, 0.72–1.49), 0.62 (0.42–1.11), 1.78 (0.99–3.63), and 0.76 (0.50–1.76) hospitalizations per 1000 residents aged <5, 5–17, 18–49, and ≥50 years, respectively. Surveillance-sampling estimated rates were 0.78 (0.46–1.22), 0.32 (0.14–0.69), 0.99 (0.64–1.52), and 1.43 (0.80–2.48) hospitalizations per 1000 residents aged <5, 5–17, 18–49, and ≥50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents.
Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.
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