Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN

Details

• Alternative Title:
  Influenza Other Respi Viruses
• Personal Author:
  Jules, Astride ; Grijalva, Carlos G. ; Zhu, Yuwei ; Talbot, Keipp H. ; Williams, John V. ; Dupont, William D. ; Edwards, Kathryn M. ; Schaffner, William ; Shay, David K. ; Griffin, Marie R.
• Description:
  Background ; In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available. ; Objectives ; To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010. ; Patients/methods ; Two separate strategies were applied: capture–recapture and surveillance-sampling methods. For the capture–recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the agespecific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system. ; Results ; With capture–recapture, we estimated 0.89 (95% CI, 0.72–1.49), 0.62 (0.42–1.11), 1.78 (0.99–3.63), and 0.76 (0.50–1.76) hospitalizations per 1000 residents aged <5, 5–17, 18–49, and ≥50 years, respectively. Surveillance-sampling estimated rates were 0.78 (0.46–1.22), 0.32 (0.14–0.69), 0.99 (0.64–1.52), and 1.43 (0.80–2.48) hospitalizations per 1000 residents aged <5, 5–17, 18–49, and ≥50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents. ; Conclusions ; Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.
• Subjects:
  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Child, Preschool
  • Female
  • Hospitalization
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza Vaccines
  More +
• Source:
  Influenza Other Respi Viruses. 2012; 6(3):e63-e71.
• Pubmed ID:
  22360812
• Pubmed Central ID:
  PMC3773818
• Document Type:
  Journal Article
• Funding:
  (U01 IP000184/IP/NCIRD CDC HHS/United States ; 1K23AI074863-01/AI/NIAID NIH HHS/United States ; M01 RR000095/RR/NCRR NIH HHS/United States ; U50 ⁄CCU 416123/PHS HHS/United States
• Place as Subject:
  Tennessee
• Volume:
  6
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/33627/cdc_33627_DS1.pdf
• File Type:
  [PDF - 767.61 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:b0668d5ba6939b305abab5acbeb1d2e30ed29c90d774dbfba45768632f2e94f2a8f408491234384a2b595488a7faaea088945225ffb96f830ee411835657e85e