Prevention of influenza in healthy children

Details

• Alternative Title:
  Expert Rev Anti Infect Ther
• Personal Author:
  Lee, Bruce Y ; Shah, Mirat
• Description:
  Healthy children are high transmitters of influenza and can experience poor influenza outcomes. Many questions remain about the efficacy and impect of preventive measures because most existing studies report imprecise proxies of influenza incidence, do not follow subjects throughout the entire influenza season and across multiple influenza seasons, or do not control for important factors such as timing of implementation and social contact patterns. Modeling and simulation are key methodologies to answer questions regarding influenza prevention. While vaccination may be the most efficacious existing intervention, variations in circulating strains and children's immune systems keep current vaccines from being fully protective, necessitating further clinical and economic studies and technology improvements. Hand hygiene appears to be an important adjunct but improving compliance, standardizing regimens and quantifying its impact remain challenging. Future studies should help better define the specific indications and circumstances for antiviral use and the role of nutritional supplements and nonpharmaceutical interventions.
• Subjects:
  Adolescent Antiviral Agents Antiviral Medications Article Child Child, Preschool Dietary Supplements Healthy Children Humans Infant Influenza Influenza, Human Influenza Prevention Influenza Vaccines Nonpharmaceutical Interventions Quarantine Vaccination

  More +
• Source:
  Expert Rev Anti Infect Ther. 2012; 10(10):1139-1152
• Pubmed ID:
  23199400
• Pubmed Central ID:
  PMC3763239
• Document Type:
  Journal Article
• Funding:
  U01 IP000467/IP/NCIRD CDC HHSUnited States/ ; U54 GM088491/GM/NIGMS NIH HHSUnited States/ ; 5U54GM088491-02/GM/NIGMS NIH HHSUnited States/
• Volume:
  10
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4c3ee3cd5e3fb547d28615f03936d5e1ff42b2701751e94cf7110f4f47ed41dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/33622/cdc_33622_DS1.pdf
• File Type:
  [PDF - 227.09 KB ]