Increasing Burden of Methicillin-Resistant Staphylococcus aureus Hospitalizations at US Academic Medical Centers, 2003–2008

David, Michael Z.; Medvedev, Sofia; Hohmann, Samuel F.; Ewigman, Bernard; Daum, Robert S.

doi:10.1086/666640

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Increasing Burden of Methicillin-Resistant Staphylococcus aureus Hospitalizations at US Academic Medical Centers, 2003–2008

Published Date:

Jun 11 2012

Publisher's site:

http://dx.doi.org/10.1086/666640 New Site Icon

Source:

Infect Control Hosp Epidemiol. 2012; 33(8):782-789.

[PDF-672.53 KB]

Details:

Personal Authors:

David, Michael Z. ; Medvedev, Sofia ; Hohmann, Samuel F. ; Ewigman, Bernard ; Daum, Robert S. ;

Keywords:

[+]

Pubmed ID:

22759545

Pubmed Central ID:

PMC3682488

Description:

OBJECTIVE

The incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections in the United States decreased during 2005–2008, but noninvasive community-associated MRSA (CA-MRSA) infections also frequently lead to hospitalization. We estimated the incidence of all MRSA infections among inpatients at US academic medical centers (AMCs) per 1,000 admissions during 2003–2008.

DESIGN

Retrospective cohort study.

SETTING AND PARTICIPANTS

Hospitalized patients at 90% of nonprofit US AMCs during 2003–2008.

METHODS

Administrative data on MRSA infections from a hospital discharge database (University HealthSystem Consortium [UHC]) were adjusted for underreporting of the MRSA V09.0 International Classification of Diseases, Ninth Revision, Clinical Modification code and validated using chart reviews for patients with known MRSA infections in 2004–2005, 2006, and 2007.

RESULTS

The mean sensitivity of administrative data for MRSA infections at the University of Chicago Medical Center in three 12-month periods during 2004–2007 was 59.1%. On the basis of estimates of billing data sensitivity from the literature and the University of Chicago Medical Center, the number of MRSA infections per 1,000 hospital discharges at US AMCs increased from 20.9 (range, 11.1–47.7) in 2003 to 41.7 (range, 21.9–94.0) in 2008. At the University of Chicago Medical Center, among infections cultured more than 3 days prior to hospital discharge, CA-MRSA infections were more likely to be captured in the UHC billing–derived data than were healthcare-associated MRSA infections.

CONCLUSIONS

The number of hospital admissions for any MRSA infection per 1,000 hospital admissions overall increased during 2003–2008. Use of unadjusted administrative hospital discharge data or surveillance for invasive disease far underestimates the number of MRSA infections among hospitalized patients.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1R01AL067584-04/PHS HHS/United States
AL040481-08A1S1/PHS HHS/United States
HHSN272200700031C/PHS HHS/United States
K23 AI095361/AI/NIAID NIH HHS/United States
R01 CI000373-03/CI/NCPDCID CDC HHS/United States

Supporting Files:

	nihms472827.nxml	text/plain
	nihms472827f1.gif	image/gif
	nihms472827f1.jpg	image/jpeg

No Related Documents.

You May Also Like:

Internet Queries and Methicillin-Resistant Staphylococcus aureus Surveillance

Personal Author:

Dukic, Vanja M.; David, Michael Z.; Lauderdale, Diane S.;

Published:

Jun 2011

Source:

Emerg Infect Dis. 17(6):1068-1070.

Description:

The Internet is a common source of medical information and has created novel surveillance opportunities. We assessed the potential for Internet-based surveillance of methicillin-resistant Staphylococcus aureus and examined the extent to which it refl...

File Type:

[PDF - 231.68 KB]
Twenty Years of Active Bacterial Core Surveillance

Personal Author:

Langley, Gayle; Schaffner, William; Farley, Monica M.; Lynfield, Ruth; Bennett, Nancy M.; Reingold, Arthur; Thomas, Ann; Harrison, Lee H.; Nichols, Megin; Petit, Susan; Miller, Lisa; Moore, Matthew R.; Schrag, Stephanie J.; Lessa, Fernanda C.; Skoff, Tami H.; MacNeil, Jessica R.; Briere, Elizabeth C.; Weston, Emily J.; Van Beneden, Chris;

Published:

Sep 2015

Source:

Emerg Infect Dis. 21(9):1520-1528.

Description:

Active Bacterial Core surveillance (ABCs) was established in 1995 as part of the Centers for Disease Control and Prevention Emerging Infections Program (EIP) network to assess the extent of invasive bacterial infections of public health importance. A...

File Type:

[PDF - 1.56 MB]
Staphylococcal Toxic Shock Syndrome 2000–2006: Epidemiology, Clinical Features, and Molecular Characteristics

Personal Author:

DeVries, Aaron S.; Lesher, Lindsey; Schlievert, Patrick M.; Rogers, Tyson; Villaume, Lourdes G.; Danila, Richard; Lynfield, Ruth;

Published:

Aug 10 2011

Source:

PLoS One. 2011; 6(8).

Description:

Introduction : Circulating strains of Staphylococcus aureus (SA) have changed in the last 30 years including the emergence of community-associated methicillin-resistant SA (MRSA). A report suggested staphylococcal toxic shock syndrome (TSS) was incre...

File Type:

[PDF - 220.32 KB]
Growth and Geographic Variation in Hospitalizations with Resistant Infections, United States, 2000–2005

Personal Author:

Zilberberg, Marya D.; Shorr, Andrew F.; Kollef, Marin H.;

Published:

Nov 2008

Source:

Emerg Infect Dis. 14(11):1756-1758.

Description:

From 2000 through 2005, hospitalizations with resistant infections (methicillin-resistant Staphylococcus aureus, Clostridium difficile-associated disease, vancomycin-resistant enterococcus, Pseudomonas aeruginosa, and Candida infection) nearly double...

File Type:

[PDF - 131.24 KB]
Antibiotic resistance threats in the United States, 2013

Corporate Author:

Centers for Disease Control and Prevention (U.S.); National Center for Emerging Zoonotic and Infectious Diseases (U.S.); National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.); National Center for Immunization and Respiratory Diseases (U.S.);

Published:

2013

Description:

This report, Antibiotic resistance threats in the United States, 2013 gives a first-ever snapshot of the burden and threats posed by the antibiotic-resistant germs having the most impact on human health. Each year in the United States, at least 2 mil...

Status:

current

File Type:

[PDF - 5.24 MB]