Details:

Alternative Title:
Infect Control Hosp Epidemiol
Publisher's site:
http://dx.doi.org/10.1086/666640
Personal Author:
David, Michael Z. ; Medvedev, Sofia ; Hohmann, Samuel F. ; Ewigman, Bernard ; Daum, Robert S.
David, Michael Z. ; Medvedev, Sofia ; Hohmann, Samuel F. ; Ewigman, Bernard ; Daum, Robert S. Less -
Description:
OBJECTIVE

The incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections in the United States decreased during 2005–2008, but noninvasive community-associated MRSA (CA-MRSA) infections also frequently lead to hospitalization. We estimated the incidence of all MRSA infections among inpatients at US academic medical centers (AMCs) per 1,000 admissions during 2003–2008.

DESIGN

Retrospective cohort study.

SETTING AND PARTICIPANTS

Hospitalized patients at 90% of nonprofit US AMCs during 2003–2008.

METHODS

Administrative data on MRSA infections from a hospital discharge database (University HealthSystem Consortium [UHC]) were adjusted for underreporting of the MRSA V09.0 International Classification of Diseases, Ninth Revision, Clinical Modification code and validated using chart reviews for patients with known MRSA infections in 2004–2005, 2006, and 2007.

RESULTS

The mean sensitivity of administrative data for MRSA infections at the University of Chicago Medical Center in three 12-month periods during 2004–2007 was 59.1%. On the basis of estimates of billing data sensitivity from the literature and the University of Chicago Medical Center, the number of MRSA infections per 1,000 hospital discharges at US AMCs increased from 20.9 (range, 11.1–47.7) in 2003 to 41.7 (range, 21.9–94.0) in 2008. At the University of Chicago Medical Center, among infections cultured more than 3 days prior to hospital discharge, CA-MRSA infections were more likely to be captured in the UHC billing–derived data than were healthcare-associated MRSA infections.

CONCLUSIONS

The number of hospital admissions for any MRSA infection per 1,000 hospital admissions overall increased during 2003–2008. Use of unadjusted administrative hospital discharge data or surveillance for invasive disease far underestimates the number of MRSA infections among hospitalized patients.


Subjects:
[+]
Academic Medical Centers Article Community-Acquired Infections Cross Infection Databases, Factual Hospital Charges Hospitalization Humans Incidence International Classification Of Diseases Medical Records Methicillin-Resistant Staphylococcus Aureus Patient Discharge Retrospective Studies Staphylococcal Infections
Source:
Infect Control Hosp Epidemiol. 2012; 33(8):782-789.
Pubmed ID:
22759545
Pubmed Central ID:
PMC3682488
Document Type:
Journal Article
Funding:
1R01AL067584-04/PHS HHS/United States ; AL040481-08A1S1/PHS HHS/United States ; HHSN272200700031C/PHS HHS/United States ; K23 AI095361/AI/NIAID NIH HHS/United States ; R01 CI000373-03/CI/NCPDCID CDC HHS/United States
1R01AL067584-04/PHS HHS/United States ; AL040481-08A1S1/PHS HHS/United States ; HHSN272200700031C/PHS HHS/United States ; K23 AI095361/AI/NIAID NIH HHS/United States ; R01 CI000373-03/CI/NCPDCID CDC HHS/United States Less -
Name as Subject:
Centers for Disease Control and Prevention (U.S.) ; Centers for Disease Control and Prevention (U.S.)
Centers for Disease Control and Prevention (U.S.) ; Centers for Disease Control and Prevention (U.S.) Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4ea8137ef931c0d2db44d6daa60ec6eb6a52216521cf142d1109f98fbf9082fd
Download URL:
https://stacks.cdc.gov/view/cdc/33582/cdc_33582_DS1.pdf
File Type:

Supporting Files

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