Welcome to CDC stacks | A multicenter study of Clostridium difficile infection-related colectomy, 2000–2006 - 33564 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
A multicenter study of Clostridium difficile infection-related colectomy, 2000–2006
  • Published Date:
    Mar 20 2012
  • Source:
    Infect Control Hosp Epidemiol. 33(5):470-476.
Filetype[PDF-910.80 KB]

  • Corporate Authors:
    CDC Prevention Epicenters Program
  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    The incidence of Clostridium difficile infection (CDI) has been increasing. Previous studies report that the number of colectomies for CDI is also rising. Outside of a few notable outbreaks, there are few published data documenting increasing severity of CDI. The specific aims of this multiyear, multicenter study were to assess CDI-related colectomy rates and compare CDI-related colectomy rates by CDI surveillance definition.


    Cases of CDI and patients who underwent colectomy were identified electronically from 5 US tertiary-care centers from July 2000 through June 2006. Chart review was performed to determine if a colectomy was for CDI. Monthly CDI-related colectomy rates were calculated as the number of CDI-related colectomies per 1,000 CDI cases. Data between observational groups were compared using χ2 and Mann-Whitney U tests. Logistic regression was performed to evaluate risk factors for CDI-related colectomy.


    8569 cases of CDI were identified and 75 patients had CDI-related colectomy. The overall colectomy rate was 8.7/1,000 CDI cases. The CDI-related colectomy rate ranged from 0 to 23 per 1,000 CDI episodes across hospitals. The colectomy rates for healthcare facility (HCF)-onset CDI was 4.3/1000 CDI cases and 16.5 /1000 CDI cases for community-onset CDI (p <.05). There were significantly more CDI-related colectomies at hospitals B and C (p<.05).


    The overall CDI-related colectomy rate was low, and there was no significant change in the CDI-related colectomy rate over time. Onset of disease outside of the study hospital was an independent risk factor for colectomy.

  • Document Type:
  • Collection(s):
  • Funding:
    5U01C1000333/PHS HHS/United States
    5U01CI000328/CI/NCPDCID CDC HHS/United States
    5U01CI000334/CI/NCPDCID CDC HHS/United States
    5U01CI000344/CI/NCPDCID CDC HHS/United States
    K01AI065808/AI/NIAID NIH HHS/United States
    K23 AI065806/AI/NIAID NIH HHS/United States
    K23AI065806/AI/NIAID NIH HHS/United States
    K24AI06779401/AI/NIAID NIH HHS/United States
    L30 AI062141/AI/NIAID NIH HHS/United States
    UR8/CCU715087-06/1/PHS HHS/United States
No Related Documents.
You May Also Like: