Welcome to CDC Stacks | FcγRI (CD64): an identity card for intestinal macrophages - 33551 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
FcγRI (CD64): an identity card for intestinal macrophages
Filetype[PDF - 695.72 KB]


Details:
  • Pubmed ID:
    23255010
  • Pubmed Central ID:
    PMC3644030
  • Description:
    Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue of the European Journal of Immunology, Tamoutounour et al. [Eur. J. Immunol. 2012. 42: 3150-3166] identify CD64 as a specific macrophage marker that can be used to discriminate DCs from macrophages in the murine small and large intestine, under both steady-state and inflammatory conditions. The authors also propose a sequential 'monocyte-waterfall' model for intestinal macrophage differentiation, with implications for immune tolerance and inflammation at the gut mucosal interface. This Commentary will discuss the advantages and potential limitations of CD64 as a marker for intestinal macrophages.

  • Document Type:
  • Collection(s):
  • Funding:
    DP2 2009A054301/DP/NCCDPHP CDC HHS/United States
    DP2 OD006512/OD/NIH HHS/United States
    P30 AI060354/AI/NIAID NIH HHS/United States
No Related Documents.
You May Also Like: