FcγRI (CD64): an identity card for intestinal macrophages

De Calisto, Jaime; Villablanca, Eduardo J.; Mora, J. Rodrigo

doi:10.1002/eji.201243061

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FcγRI (CD64): an identity card for intestinal macrophages

Published Date:

Dec 2012

Publisher's site:

http://dx.doi.org/10.1002/eji.201243061 New Site Icon

Source:

Eur J Immunol. 42(12):3136-3140.

[PDF-695.72 KB]

Details:

Personal Authors:

De Calisto, Jaime ; Villablanca, Eduardo J. ; Mora, J. Rodrigo ;

Keywords:

[+]

Pubmed ID:

23255010

Pubmed Central ID:

PMC3644030

Description:

Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue of the European Journal of Immunology, Tamoutounour et al. [Eur. J. Immunol. 2012. 42: 3150-3166] identify CD64 as a specific macrophage marker that can be used to discriminate DCs from macrophages in the murine small and large intestine, under both steady-state and inflammatory conditions. The authors also propose a sequential 'monocyte-waterfall' model for intestinal macrophage differentiation, with implications for immune tolerance and inflammation at the gut mucosal interface. This Commentary will discuss the advantages and potential limitations of CD64 as a marker for intestinal macrophages.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 2009A054301/DP/NCCDPHP CDC HHS/United States
DP2 OD006512/OD/NIH HHS/United States
P30 AI060354/AI/NIAID NIH HHS/United States

Main Document Checksum:

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Supporting Files:

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	nihms-461060-f0001.jpg	image/jpeg
	nihms-461060.nxml	application/octet-stream

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