FcγRI (CD64): an identity card for intestinal macrophages

Details

• Alternative Title:
  Eur J Immunol
• Personal Author:
  De Calisto, Jaime ; Villablanca, Eduardo J. ; Mora, J. Rodrigo
• Description:
  Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue of the European Journal of Immunology, Tamoutounour et al. [Eur. J. Immunol. 2012. 42: 3150-3166] identify CD64 as a specific macrophage marker that can be used to discriminate DCs from macrophages in the murine small and large intestine, under both steady-state and inflammatory conditions. The authors also propose a sequential 'monocyte-waterfall' model for intestinal macrophage differentiation, with implications for immune tolerance and inflammation at the gut mucosal interface. This Commentary will discuss the advantages and potential limitations of CD64 as a marker for intestinal macrophages.
• Subjects:
  Animals Colitis Dendritic Cells Humans Intestinal Mucosa Lymph Nodes Macrophages Mesentery Receptors, IgG Th1 Cells
• Source:
  Eur J Immunol. 42(12):3136-3140.
• Pubmed ID:
  23255010
• Pubmed Central ID:
  PMC3644030
• Document Type:
  Journal Article
• Funding:
  DP2 2009A054301/DP/NCCDPHP CDC HHS/United States ; DP2 OD006512/OD/NIH HHS/United States ; P30 AI060354/AI/NIAID NIH HHS/United States
• Volume:
  42
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:00d39dbbf8c645d23fbda80144b875a79cc7e4846c747044d561a82d1db3dd41
• Download URL:
  https://stacks.cdc.gov/view/cdc/33551/cdc_33551_DS1.pdf
• File Type:
  [PDF - 695.72 KB ]