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FcγRI (CD64): an identity card for intestinal macrophages
Filetype[PDF-695.72 KB]


Details:
  • Personal Authors:
  • Keywords:
  • Pubmed ID:
    23255010
  • Pubmed Central ID:
    PMC3644030
  • Description:
    Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue of the European Journal of Immunology, Tamoutounour et al. [Eur. J. Immunol. 2012. 42: 3150-3166] identify CD64 as a specific macrophage marker that can be used to discriminate DCs from macrophages in the murine small and large intestine, under both steady-state and inflammatory conditions. The authors also propose a sequential 'monocyte-waterfall' model for intestinal macrophage differentiation, with implications for immune tolerance and inflammation at the gut mucosal interface. This Commentary will discuss the advantages and potential limitations of CD64 as a marker for intestinal macrophages.

  • Document Type:
    Journal Article
  • Collection(s):
    CDC Public Access
  • Funding:
    DP2 2009A054301/DP/NCCDPHP CDC HHS/United States
    DP2 OD006512/OD/NIH HHS/United States
    P30 AI060354/AI/NIAID NIH HHS/United States
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