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HCMV gB shares structural and functional properties with gB proteins from other herpesviruses
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    Stampfer, Samuel D.; Heldwein, Ekaterina E.;
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    Oct 26 2012
    Source:
    Curr Opin Virol. 2012; 3(1):13-19.
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    Enveloped viruses enter cells by fusing the viral and cellular membranes, and most use a single viral envelope protein that combines receptor-binding and fusogenic functions. In herpesviruses, these functions are distributed among multiple proteins: ...
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    Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-mach...
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    Viral fusogens mediate the merger of the viral envelope and cellular membrane during viral entry. These proteins share little sequence similarity but all are thought to act by refolding through a series of conformational intermediates from the metast...
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    Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. Primary infection with HHV-6B causes roseola infantum or exanthem subitum, a com...
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    Watanabe, Shumpei; Maeda, Ken; Suzuki, Kazuo; Ueda, Naoya; Iha, Koichiro; Taniguchi, Satoshi; Shimoda, Hiroshi; Kato, Kentaro; Yoshikawa, Yasuhiro; Morikawa, Shigeru; Kurane, Ichiro; Akashi, Hiroomi; Mizutani, Tetsuya;
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    Because bats are associated with emerging zoonoses, identification and characterization of novel viruses from bats is needed. Using a modified rapid determination system for viral RNA/DNA sequences, we identified a novel bat betaherpesvirus 2 not det...
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