Details:

Alternative Title:
J Infect
Personal Author:
Han, Jennifer H. ; Edelstein, Paul H. ; Bilker, Warren B. ; Lautenbach, Ebbing
Han, Jennifer H. ; Edelstein, Paul H. ; Bilker, Warren B. ; Lautenbach, Ebbing Less -
Description:
Objectives

The impact of staphylococcal cassette chromosome mec (SCCmec) type on mortality in methicillin-resistant Staphylococcus aureus (MRSA) infections remains unclear. The objective of this study was to determine the association between SCCmec type and mortality in MRSA bacteremia.

Methods

A cohort study of patients who were hospitalized with MRSA bacteremia was conducted within a university health system. A multivariable logistic regression model was developed to evaluate the association of SCCmec type with 30-day in-hospital mortality.

Results

Thirty-four of a total of 184 patients with MRSA bacteremia died, resulting in a mortality rate of 18.5%. Adjusted risk factors for 30-day mortality included APRDRG Risk of Mortality score (odds ratio [OR], 5.33; 95% confidence interval [CI], 2.28-12.4; P<0.001), white blood cell count (OR, 1.09; 95% CI, 1.03-1.15; P=0.002), and malignancy (OR, 3.25; 95% CI, 1.17-9.02; P=0.02). On multivariable analyses, SCCmec II was not significantly associated with mortality in patients with MRSA bacteremia (OR, 1.85; 95% CI, 0.69-4.92; P=0.22).

Conclusions

Mortality in MRSA bacteremia was independent of SCCmec type. SCCmec type II is most likely a marker for disease severity rather than a direct mediator of mortality. Further research is needed to elucidate the factors associated with poor clinical outcomes in MRSA infections.


Subjects:
[+]
Article Bacteremia Bacterial Proteins Cohort Studies Female Hospitalization Humans Male Methicillin-resistant Methicillin-Resistant Staphylococcus Aureus Methicillin Resistance Middle Aged Molecular Typing Multivariate Analysis Odds Ratio Outcomes Penicillin-Binding Proteins Retrospective Studies Risk Factors Staphylococcal Infections Staphylococcus Aureus Survival Rate Treatment Outcome
Source:
J Infect. 2012; 66(1):41-47.
Pubmed ID:
22960078
Pubmed Central ID:
PMC3518704
Document Type:
Journal Article
Funding:
K24 AI080942/AI/NIAID NIH HHS/United States ; L30 AI101162/AI/NIAID NIH HHS/United States ; U54 CK000163/CK/NCEZID CDC HHS/United States ; U54-CK000163/CK/NCEZID CDC HHS/United States
K24 AI080942/AI/NIAID NIH HHS/United States ; L30 AI101162/AI/NIAID NIH HHS/United States ; U54 CK000163/CK/NCEZID CDC HHS/United States ; U54-CK000163/CK/NCEZID CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:24bb8bbda7639a10a6bada3e6905bac73526d5f55bd9c3972bcc9596778bdd0d
Download URL:
https://stacks.cdc.gov/view/cdc/33491/cdc_33491_DS1.pdf
File Type:

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