Neural Tube Defects and Maternal Intake of Micronutrients Related to One-Carbon Metabolism or Antioxidant Activity

Chandler, Angela L.; Hobbs, Charlotte A.; Mosley, Bridget S.; Berry, Robert J.; Canfield, Mark A.; Qi, Yan Ping; Siega-Riz, Anna Maria; Shaw, Gary M.

doi:10.1002/bdra.23068

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Neural Tube Defects and Maternal Intake of Micronutrients Related to One-Carbon Metabolism or Antioxidant Activity

Published Date:

Aug 29 2012

Publisher's site:

http://dx.doi.org/10.1002/bdra.23068 New Site Icon

Source:

Birth Defects Res A Clin Mol Teratol. 94(11):864-874.

[PDF-84.13 KB]

Details:

Personal Authors:

Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; ... More ▼

Corporate Authors:

National Birth Defects Prevention Study

Keywords:

[+]

Pubmed ID:

22933447

Pubmed Central ID:

PMC3518275

Description:

Background

Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs.

Objective

The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.

Design

Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.

Results

Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.

Conclusion

In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

5U01DD000491/DD/NCBDD CDC HHS/United States
DK56350/DK/NIDDK NIH HHS/United States
R01 NS050249/NS/NINDS NIH HHS/United States
R01NS050249/NS/NINDS NIH HHS/United States

Supporting Files:

nihms415393.nxml

text/plain

No Related Documents.

You May Also Like:

Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization?

Personal Author:

Nakouzi, Ghunwa A; Nadeau, Joseph H;

Published:

Aug 27 2014

Source:

BMC Genet. 2014; 15:91.

Description:

Background : Neural tube defects (NTDs) are the second most common birth defect in humans. Dietary folic acid (FA) supplementation effectively and safely reduces the incidence of these often debilitating congenital anomalies. FA plays an established ...

File Type:

[PDF - 1.06 MB]
Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

Personal Author:

Crider, Krista S.; Bailey, Lynn B.; Berry, Robert J.;

Published:

Mar 15 2011

Source:

Nutrients. 2011; 3(3):370-384.

Description:

Periconceptional intake of folic acid is known to reduce a woman's risk of having an infant affected by a neural tube birth defect (NTD). National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide...

File Type:

[PDF - 206.00 KB]
Folate Deficiency Is Prevalent in Women of Childbearing Age in Belize and Is Negatively Affected by Coexisting Vitamin B-12 Deficiency: Belize National Micronutrient Survey 20111–4

Personal Author:

Rosenthal, Jorge; Largaespada, Natalia; Bailey, Lynn B; Cannon, Michael; Alverson, CJ; Ortiz, Dayrin; Kauwell, Gail PA; Sniezek, Joe; Figueroa, Ramon; Daly, Robyn; Allen, Peter;

Published:

Apr 12 2017

Source:

J Nutr. 147(6):1183-1193.

Description:

Background : Folate deficiency, vitamin B-12 deficiency, and anemia can have adverse effects on birth outcomes. Also, low vitamin B-12 reduces the formation of metabolically active folate. : Objectives : We sought to establish the baseline prevalence...

File Type:

[PDF - 1.21 MB]
Sequence Variation in Folate Pathway Genes and Risks of Human Cleft Lip with or without Cleft Palate

Personal Author:

Marini, Nicholas J.; Yang, Wei; Asrani, Kripa; Witte, John S.; Rine, Jasper; Lammer, Edward J.; Shaw, Gary M.;

Published:

Sep 08 2016

Source:

Am J Med Genet A. 170(11):2777-2787.

Description:

In an effort to comprehensively interrogate genetic variation in the folate pathway for risk of cleft lip with or without cleft palate (CLP), we evaluated 504 common and rare variants in 35 folate-related genes in a panel of 330 infants with CLP and ...

File Type:

[PDF - 383.00 KB]
Folate-related gene variants in Irish families affected by neural tube defects

Personal Author:

Fisk Green, Ridgely; Byrne, Julianne; Crider, Krista S.; Gallagher, Margaret; Koontz, Deborah; Berry, Robert J.;

Published:

Nov 06 2013

Source:

Front Genet. 2013; 4.

Description:

Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of genes involved in folate metabolism in mothers and children have been associated with occurrence of NTDs. We identified Irish families with individuals affected...

File Type:

[PDF - 449.41 KB]