Neural Tube Defects and Maternal Intake of Micronutrients Related to One-Carbon Metabolism or Antioxidant Activity

Chandler, Angela L.; Hobbs, Charlotte A.; Mosley, Bridget S.; Berry, Robert J.; Canfield, Mark A.; Qi, Yan Ping; Siega-Riz, Anna Maria; Shaw, Gary M.

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Neural Tube Defects and Maternal Intake of Micronutrients Related to One-Carbon Metabolism or Antioxidant Activity

Published Date:

Aug 29 2012

Source:

Birth Defects Res A Clin Mol Teratol. 94(11):864-874

Language:

English

[PDF-84.13 KB]

Details:

Personal Authors:

Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; ... More ▼

Corporate Authors:

National Birth Defects Prevention Study

Keywords:

[+]

Pubmed ID:

22933447

Pubmed Central ID:

PMC3518275

Description:

Background

Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs.

Objective

The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.

Design

Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.

Results

Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.

Conclusion

In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U01 DD000491/DD/NCBDD CDC HHS/United States
5U01DD000491/DD/NCBDD CDC HHS/United States
DK56350/DK/NIDDK NIH HHS/United States
R01 NS050249/NS/NINDS NIH HHS/United States
R01NS050249/NS/NINDS NIH HHS/United States
P30 DK056350/DK/NIDDK NIH HHS/United States

Supporting Files:

nihms415393.nxml

text/xml

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