Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; ... More +
Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; Qi, Yan Ping ; Siega-Riz, Anna Maria ; Shaw, Gary M. Less -
Corporate Authors:
National Birth Defects Prevention Study
Description:
Background

Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs.

Objective

The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.

Design

Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.

Results

Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.

Conclusion

In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.


Subjects:
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Adult Antioxidants Black People Body Mass Index Carbon Case-Control Studies Dietary Supplements Female Folic Acid Health Surveys Hispanic Or Latino Humans Logistic Models Male Maternal Nutritional Physiological Phenomena Micronutrients Neural Tube Defects Pregnancy Risk Factors Vitamins White People
Source:
Birth Defects Res A Clin Mol Teratol. 94(11):864-874
Pubmed ID:
22933447
Pubmed Central ID:
PMC3518275
Document Type:
Journal Article
Funding:
U01 DD000491/DD/NCBDD CDC HHS/United States ; 5U01DD000491/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States ; R01 NS050249/NS/NINDS NIH HHS/United States ; R01NS050249/NS/NINDS NIH HHS/United States ; ... More +
U01 DD000491/DD/NCBDD CDC HHS/United States ; 5U01DD000491/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States ; R01 NS050249/NS/NINDS NIH HHS/United States ; R01NS050249/NS/NINDS NIH HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:69dc475a62f93cb082bb4ba083252c8e97e9bb75c971e0dc45dc59c19a1db2bd
Download URL:
https://stacks.cdc.gov/view/cdc/33488/cdc_33488_DS1.pdf
File Type:

Supporting Files

• nihms415393.nxml

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