Neural Tube Defects and Maternal Intake of Micronutrients Related to One-Carbon Metabolism or Antioxidant Activity
Published Date:Aug 29 2012
Source:Birth Defects Res A Clin Mol Teratol. 94(11):864-874.
Corporate Authors:National Birth Defects Prevention Study
African Continental Ancestry Group
Body Mass Index
Dietary Periconceptional Micronutrients
European Continental Ancestry Group
Maternal Nutritional Physiological Phenomena
National Birth Defects Prevention Study
Neural Tube Defects
Pubmed Central ID:PMC3518275
Funding:5U01DD000491/DD/NCBDD CDC HHS/United States
DK56350/DK/NIDDK NIH HHS/United States
R01 NS050249/NS/NINDS NIH HHS/United States
R01NS050249/NS/NINDS NIH HHS/United States
Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs.
The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.
Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.
Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.
In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.
You May Also Like: