Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; ... More +
Chandler, Angela L. ; Hobbs, Charlotte A. ; Mosley, Bridget S. ; Berry, Robert J. ; Canfield, Mark A. ; Qi, Yan Ping ; Siega-Riz, Anna Maria ; Shaw, Gary M. ; Less -
Corporate Authors:
National Birth Defects Prevention Study ;
Description:
Background Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. Objective The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity. Design Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake. Results Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida. Conclusion In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.
Subject:
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Adult
African Continental Ancestry Group
Antioxidants
Body Mass Index
Carbon
Case-Control Studies
Dietary Supplements
European Continental Ancestry Group
Female
Folic Acid
Health Surveys
Hispanic Americans
Humans
Logistic Models
Male
Maternal Nutritional Physiological Phenomena
Micronutrients
Neural Tube Defects
Pregnancy
Risk Factors
Vitamins

Source:
Birth Defects Res A Clin Mol Teratol. 94(11):864-874
Pubmed ID:
22933447
Pubmed Central ID:
PMC3518275
Document Type:
Journal Article ;
Funding:
U01 DD000491/DD/NCBDD CDC HHS/United States ; 5U01DD000491/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States ; R01 NS050249/NS/NINDS NIH HHS/United States ; R01NS050249/NS/NINDS NIH HHS/United States ; ... More +
U01 DD000491/DD/NCBDD CDC HHS/United States ; 5U01DD000491/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States ; R01 NS050249/NS/NINDS NIH HHS/United States ; R01NS050249/NS/NINDS NIH HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States ; Less -
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:69dc475a62f93cb082bb4ba083252c8e97e9bb75c971e0dc45dc59c19a1db2bd
File Type:

Supporting Files

• nihms415393.nxml

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