Higher Population-Based Incidence Rates of Triple-Negative Breast Cancer Among Young African American Women: Implications for Breast Cancer Screening Recommendations
Published Date:Jan 10 2011
Pubmed Central ID:PMC3461243
Funding:1U58DP00807-01/DP/NCCDPHP CDC HHS/United States
N01 PC035136/PC/NCI NIH HHS/United States
N01 PC035139/PC/NCI NIH HHS/United States
Differences in the breast cancer burden of African American compared with White American women are well-documented. Recent controversies have emerged regarding age-appropriate mammographic screening guidelines, and these surveillance recommendations may influence future breast cancer disparities. Our goal was to evaluate age-specific breast cancer stage distributions and incidence rates of triple-negative breast cancer (TNBC) in a population-based tumor registry.
We analyzed California Cancer Registry (CCR) breast cancers diagnosed 1988 – 2006. Results were stratified by age and race/ethnicity, with White Americans identified as Non-Hispanic Whites (NHW) and African Americans as Non-Hispanic Blacks (NHB). Breast cancer stage distributions and TNBC incidence rates were also analyzed.
A total of 375,761 invasive breast cancers were evaluated (including 276,938 in NHW and 21,681 in NHB) NHB and Hispanics tended to be younger than NHW (median ages 57; 54; and 64 years, respectively). Lifetime incidence rates were higher for NHW compared to NHB and Hispanics, but for women younger than 44 years incidence was highest among NHB. NHB also had higher incidence rates of Stage III and IV disease, and higher incidence of TNBC in all age categories.
Population-based data demonstrate that African American women have a more advanced stage distribution for breast cancer compared to White Americans, and higher incidence rates for TNBC. These patterns are observed for women age 40–49 years as well as older women, and suggest that mammographic screening for early detection of breast cancer will be particularly relevant for younger African American women.
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