Tailoring of Membrane Proteins by Alternative Splicing of Pre-mRNA†

Mittendorf, Kathleen F.; Deatherage, Catherine L.; Ohi, Melanie D.; Sanders, Charles R.

doi:10.1021/bi3007065

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Tailoring of Membrane Proteins by Alternative Splicing of Pre-mRNA†

Published Date:

Jun 29 2012

Publisher's site:

http://dx.doi.org/10.1021/bi3007065

Source:

Biochemistry. 51(28):5541-5556.

[PDF-3.47 MB]

Details:

Alternative Title:

Biochemistry

Personal Author:

Mittendorf, Kathleen F. ; Deatherage, Catherine L. ; Ohi, Melanie D. ; Sanders, Charles R. ;

Description:

Alternative splicing (AS) of RNA is a key mechanism for diversification of the eukaryotic proteome. In this process, different mRNA transcripts can be produced through altered excision and/or inclusion of exons during processing of the pre-mRNA molecule. Since its discovery, AS has been shown to play roles in protein structure, function, and localization. Dysregulation of this process can result in disease phenotypes. Moreover, AS pathways are promising therapeutic targets for a number of diseases. Integral membrane proteins (MPs) represent a class of proteins that may be particularly amenable to regulation by alternative splicing because of the distinctive topological restraints associated with their folding, structure, trafficking, and function. Here, we review the impact of AS on MP form and function and the roles of AS in MP-related disorders such as Alzheimer's disease.

Subject:

[+]

Pubmed ID:

22708632

Pubmed Central ID:

PMC3448030

Document Type:

Journal Article

Funding:

1DP20D004483/DP/NCCDPHP CDC HHS/United States ; P01 GM080512/GM/NIGMS NIH HHS/United States ; P01 GM080513/GM/NIGMS NIH HHS/United States ; R01 DC007416/DC/NIDCD NIH HHS/United States ; R01 DC007416/DC/NIDCD NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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