Engineering nanomedicines using stimuli-responsive biomaterials

Wang, Yapei; Byrne, James D.; Napier, Mary E.; DeSimone, Joseph M.

doi:10.1016/j.addr.2012.01.003

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Engineering nanomedicines using stimuli-responsive biomaterials

Published Date:

Jan 14 2012

Publisher's site:

http://dx.doi.org/10.1016/j.addr.2012.01.003 New Site Icon

Source:

Adv Drug Deliv Rev. 2011; 64(11):1021-1030.

[PDF-4.16 MB]

Details:

Alternative Title:

Adv Drug Deliv Rev

Personal Author:

Wang, Yapei ; Byrne, James D. ; Napier, Mary E. ; DeSimone, Joseph M. ;

Description:

The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers.

Subject:

[+]

Pubmed ID:

22266128

Pubmed Central ID:

PMC3422739

Document Type:

Journal Article

Funding:

1DP10D006432-01/DP/NCCDPHP CDC HHS/United States ; 1R01EB009565-02/EB/NIBIB NIH HHS/United States ; DP1 CA174425/CA/NCI NIH HHS/United States ; DP1 OD006432/OD/NIH HHS/United States ; R01 EB009565/EB/NIBIB NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	nihms394128f4.jpg	image/jpeg
	nihms394128f5.gif	image/gif
	nihms394128f5.jpg	image/jpeg
	nihms394128f6.gif	image/gif
	nihms394128f6.jpg	image/jpeg
	nihms394128f7.gif	image/gif
	nihms394128f7.jpg	image/jpeg
	nihms394128f8.gif	image/gif
	nihms394128f8.jpg	image/jpeg
	nihms394128.nxml	application/octet-stream
	nihms394128f1.gif	image/gif
	nihms394128f1.jpg	image/jpeg
	nihms394128f2.gif	image/gif
	nihms394128f2.jpg	image/jpeg
	nihms394128f3.gif	image/gif
	nihms394128f3.jpg	image/jpeg
	nihms394128f4.gif	image/gif

No Related Documents.

You May Also Like:

3D Printed Programmable Release Capsules

Personal Author:

Gupta, Maneesh K.; Meng, Fanben; Johnson, Blake N.; Kong, Yong Lin; Tian, Limei; Yeh, Yao-Wen; Masters, Nina; Singamaneni, Srikanth; McAlpine, Michael C.;

Published Date:

Jun 08 2015

Source:

Nano Lett. 15(8):5321-5329.

Description:

The development of methods for achieving precise spatiotemporal control over chemical and biomolecular gradients could enable significant advances in areas such as synthetic tissue engineering, biotic-abiotic interfaces, and bionanotechnology. Living...

File Type:

[PDF - 2.40 MB]
Versatile FRET-Based Mesoporous Silica Nanoparticles for Real-Time Monitoring of Drug Release

Personal Author:

Lai, Jinping; Shah, Birju P.; Garfunkel, Eric; Lee, Ki-Bum;

Published Date:

Mar 11 2013

Source:

ACS Nano. 7(3):2741-2750.

Description:

We describe the development of a versatile fluorescence resonance energy transfer (FRET)-based real-time monitoring system, consisting of (a) coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) as the drug carrier, (b) a fluores...

File Type:

[PDF - 1.99 MB]
A Multi-Targeted Drug Delivery Vehicle Approach that Targets, Triggers, and Thermally Ablates HER2+ Breast Cancer Cells**

Personal Author:

You, Jin-Oh; Guo, Peng; Auguste, Debra T.;

Published Date:

March 11 2013

Source:

Angew Chem Int Ed Engl. 52(15):4141-4146

File Type:

[PDF - 571.78 KB]
Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer

Personal Author:

Yin, Perry T.; Shah, Shreyas; Pasquale, Nicholas J.; Garbuzenko, Olga B.; Minko, Tamara; Lee, Ki-Bum;

Published Date:

Nov 12 2015

Source:

Biomaterials. 81:46-57.

Description:

Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-ba...

File Type:

[PDF - 2.13 MB]
Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive Acoustic Biosensing

Personal Author:

Chattaraj, Rajarshi; Mohan, Praveena; Besmer, Jeremy D.; Goodwin, Andrew P.;

Published Date:

Jun 17 2015

Source:

Adv Healthc Mater. 4(12):1790-1795.

Description:

Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Strep...

File Type:

[PDF - 1.03 MB]