Engineering nanomedicines using stimuli-responsive biomaterials

Details

• Alternative Title:
  Adv Drug Deliv Rev
• Personal Author:
  Wang, Yapei ; Byrne, James D. ; Napier, Mary E. ; DeSimone, Joseph M.
• Description:
  The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers.
• Subjects:
  Biocompatible Materials Drug Delivery Systems Nanomedicine Nanoparticles Nanotechnology
• Keywords:
  Microfluidic Photolithography PRINT Top-down Trigger-release
• Source:
  Adv Drug Deliv Rev. 2011; 64(11):1021-1030
• Pubmed ID:
  22266128
• Pubmed Central ID:
  PMC3422739
• Document Type:
  Journal Article
• Funding:
  U54 CA119343/CA/NCI NIH HHSUnited States/ ; 1R01EB009565-02/EB/NIBIB NIH HHSUnited States/ ; R01 EB009565/EB/NIBIB NIH HHSUnited States/ ; R01 U54CA119373/CA/NCI NIH HHSUnited States/ ; 1DP10D006432-01/DP/NCCDPHP CDC HHSUnited States/ ; DP1 CA174425/CA/NCI NIH HHSUnited States/ ; U54 CA151652/CA/NCI NIH HHSUnited States/ ; DP1 OD006432/OD/NIH HHSUnited States/
• Volume:
  64
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c8f1626a79a71a5fc96882e0262e4f4405458ff64598027dcf9e6b1fd507c617
• Download URL:
  https://stacks.cdc.gov/view/cdc/33419/cdc_33419_DS1.pdf
• File Type:
  [PDF - 4.16 MB ]