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Engineering nanomedicines using stimuli-responsive biomaterials
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  • Description:
    The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers.

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    1DP10D006432-01/DP/NCCDPHP CDC HHS/United States
    1R01EB009565-02/EB/NIBIB NIH HHS/United States
    DP1 CA174425/CA/NCI NIH HHS/United States
    DP1 OD006432/OD/NIH HHS/United States
    R01 EB009565/EB/NIBIB NIH HHS/United States
    R01 U54CA119373/CA/NCI NIH HHS/United States
    U54 CA119343/CA/NCI NIH HHS/United States
    U54 CA151652/CA/NCI NIH HHS/United States
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