i
Engineering nanomedicines using stimuli-responsive biomaterials
-
Published Date:
January 14 2012
Source:Adv Drug Deliv Rev. 2011; 64(11):1021-1030Language:English
Details:
-
Alternative Title:Adv Drug Deliv Rev
-
Personal Author:
-
Description:The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers.
-
Subject:
-
Pubmed ID:22266128
-
Pubmed Central ID:PMC3422739
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
image/jpeg image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg text/xml image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg image/gif
No Related Documents.