Details:

Alternative Title:
Pediatr Infect Dis J
Publisher's site:
http://dx.doi.org/10.1097/INF.0b013e31824acc33
Personal Author:
Doby, Elizabeth H.; Benjamin, Daniel K.; Blaschke, Anne J.; Ward, Robert M.; Pavia, Andrew T.; ... More +
Doby, Elizabeth H.; Benjamin, Daniel K.; Blaschke, Anne J.; Ward, Robert M.; Pavia, Andrew T.; Martin, Paul L.; Driscoll, Timothy A.; Cohen-Wolkowiez, Michael; Moran, Cassandra; Less -
Description:
Voriconazole is the treatment of choice for invasive aspergillosis and its use is increasing in pediatrics. Minimal pharmacokinetic data exist in young children. We report voriconazole concentrations for 10 children <3 years of age and pharmacokinetic parameters for 1 infant who had therapeutic drug monitoring performed. Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.
Subject:
[+]
Antifungal Agents
Article
Child, Preschool
Drug Monitoring
Female
Humans
Infant
Invasive Aspergillosis
Invasive Pulmonary Aspergillosis
Male
Pediatric
Pharmacokinetic
Plasma
Pyrimidines
Therapeutic Drug Monitoring
Triazoles
Voriconazole
Voriconazole

Source:
Pediatr Infect Dis J. 31(6):632-635.;
Pubmed ID:
22301479
Pubmed Central ID:
PMC3356483
Document Type:
Journal Article;
Funding:
1K23AI079401/AI/NIAID NIH HHS/United States; 1K23HD064814-01/HD/NICHD NIH HHS/United States; 1K24HD058735-01/HD/NICHD NIH HHS/United States; 1R01AI089489-01/AI/NIAID NIH HHS/United States; 1R01FD003519-01/FD/FDA HHS/United States; ... More +
1K23AI079401/AI/NIAID NIH HHS/United States; 1K23HD064814-01/HD/NICHD NIH HHS/United States; 1K24HD058735-01/HD/NICHD NIH HHS/United States; 1R01AI089489-01/AI/NIAID NIH HHS/United States; 1R01FD003519-01/FD/FDA HHS/United States; 1R01HD057956-02/HD/NICHD NIH HHS/United States; 1U01AI082184-01/AI/NIAID NIH HHS/United States; 1U10-HD45962-06/HD/NICHD NIH HHS/United States; 1U181P000303/PHS HHS/United States; 1U18IP000303-01/IP/NCIRD CDC HHS/United States; 1UL 1RR024128-01/RR/NCRR NIH HHS/United States; 3UL1RR025764-02S3/RR/NCRR NIH HHS/United States; HD060559-01/HD/NICHD NIH HHS/United States; HHSN267200700051C/HD/NICHD NIH HHS/United States; K23 AI079401/AI/NIAID NIH HHS/United States; K23 AI079401-01A1/AI/NIAID NIH HHS/United States; K23 HD064814/HD/NICHD NIH HHS/United States; K23 HD064814-01/HD/NICHD NIH HHS/United States; K24 HD058735/HD/NICHD NIH HHS/United States; K24 HD058735-01A1/HD/NICHD NIH HHS/United States; R01 AI089489-01/AI/NIAID NIH HHS/United States; R01 HD057956/HD/NICHD NIH HHS/United States; R01 HD057956-02/HD/NICHD NIH HHS/United States; R01 HD060559/HD/NICHD NIH HHS/United States; R01 HD060559-01A1/HD/NICHD NIH HHS/United States; R01 HD060559-02/HD/NICHD NIH HHS/United States; U01 AI082184-01/AI/NIAID NIH HHS/United States; U01-AI74419/AI/NIAID NIH HHS/United States; UL1 RR024128/RR/NCRR NIH HHS/United States; UL1 RR024128-01/RR/NCRR NIH HHS/United States; UL1 RR025764/RR/NCRR NIH HHS/United States; UL1 RR025764-02S3/RR/NCRR NIH HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3b03f428bc94aa80844d13d0c7e44847dcc4d1d2d40b8393e5720459c9aac376
File Type:

Supporting Files

• 	nihms356601.nxml	txt
  	nihms356601f1.gif	gif
  	nihms356601f1.jpg	jpeg

More +