Therapeutic Monitoring of Voriconazole in Children Less Than 3 Years of Age: A Case Report and Summary of Voriconazole Concentrations for 10 Children

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Doby, Elizabeth H. ; Benjamin, Daniel K. ; Blaschke, Anne J. ; Ward, Robert M. ; Pavia, Andrew T. ; Martin, Paul L. ; Driscoll, Timothy A. ; Cohen-Wolkowiez, Michael ; Moran, Cassandra
• Description:
  Voriconazole is the treatment of choice for invasive aspergillosis and its use is increasing in pediatrics. Minimal pharmacokinetic data exist in young children. We report voriconazole concentrations for 10 children <3 years of age and pharmacokinetic parameters for 1 infant who had therapeutic drug monitoring performed. Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.
• Subjects:
  Antifungal Agents Article Child, Preschool Drug Monitoring Female Humans Infant Invasive Aspergillosis Invasive Pulmonary Aspergillosis Male Pediatric Pharmacokinetic Plasma Pyrimidines Therapeutic Drug Monitoring Triazoles Voriconazole

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• Source:
  Pediatr Infect Dis J. 31(6):632-635
• Pubmed ID:
  22301479
• Pubmed Central ID:
  PMC3356483
• Document Type:
  Journal Article
• Funding:
  HHSN267200700051C/HD/NICHD NIH HHSUnited States/ ; K24 HD058735/HD/NICHD NIH HHSUnited States/ ; U01-AI74419/AI/NIAID NIH HHSUnited States/ ; UL1 RR025764/RR/NCRR NIH HHSUnited States/ ; R01 HD057956/HD/NICHD NIH HHSUnited States/ ; UL1 RR025764-02S3/RR/NCRR NIH HHSUnited States/ ; 3UL1RR025764-02S3/RR/NCRR NIH HHSUnited States/ ; 1UL 1RR024128-01/RR/NCRR NIH HHSUnited States/ ; 1K23AI079401/AI/NIAID NIH HHSUnited States/ ; 1K24HD058735-01/HD/NICHD NIH HHSUnited States/ ; 1R01FD003519-01/FD/FDA HHSUnited States/ ; R01 HD057956-02/HD/NICHD NIH HHSUnited States/ ; 1K23HD064814-01/HD/NICHD NIH HHSUnited States/ ; UL1 RR024128-01/RR/NCRR NIH HHSUnited States/ ; UL1 RR024128/RR/NCRR NIH HHSUnited States/ ; U01 AI082184-01/AI/NIAID NIH HHSUnited States/ ; 1R01HD057956-02/HD/NICHD NIH HHSUnited States/ ; 1U18IP000303-01/IP/NCIRD CDC HHSUnited States/ ; K23 AI079401/AI/NIAID NIH HHSUnited States/ ; U01 AI074419/AI/NIAID NIH HHSUnited States/ ; U01 AI082184/AI/NIAID NIH HHSUnited States/ ; K23 AI079401-01A1/AI/NIAID NIH HHSUnited States/ ; 1R01AI089489-01/AI/NIAID NIH HHSUnited States/ ; K23 HD064814/HD/NICHD NIH HHSUnited States/ ; K24 HD058735-01A1/HD/NICHD NIH HHSUnited States/ ; R01 HD060559/HD/NICHD NIH HHSUnited States/ ; U10 HD045962/HD/NICHD NIH HHSUnited States/ ; U18 IP000303/IP/NCIRD CDC HHSUnited States/ ; R01 HD060559-02/HD/NICHD NIH HHSUnited States/ ; 1U01AI082184-01/AI/NIAID NIH HHSUnited States/ ; 1U10-HD45962-06/HD/NICHD NIH HHSUnited States/ ; K23 HD064814-01/HD/NICHD NIH HHSUnited States/ ; R01 AI089489-01/AI/NIAID NIH HHSUnited States/ ; HD060559-01/HD/NICHD NIH HHSUnited States/ ; R01 HD060559-01A1/HD/NICHD NIH HHSUnited States/ ; 1U181P000303/PHS HHSUnited States/ ; R01 FD003519/FD/FDA HHSUnited States/ ; R01 AI089489/AI/NIAID NIH HHSUnited States/
• Volume:
  31
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3b03f428bc94aa80844d13d0c7e44847dcc4d1d2d40b8393e5720459c9aac376
• Download URL:
  https://stacks.cdc.gov/view/cdc/33364/cdc_33364_DS1.pdf
• File Type:
  [PDF - 71.11 KB ]