Relations among Posttraumatic Stress Disorder, Comorbid Major Depression, and HPA Function: A Systematic Review and Meta-Analysis

Morris, Matthew C.; Compas, Bruce E.; Garber, Judy

doi:10.1016/j.cpr.2012.02.002

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Relations among Posttraumatic Stress Disorder, Comorbid Major Depression, and HPA Function: A Systematic Review and Meta-Analysis

Published Date:

Feb 10 2012

Publisher's site:

http://dx.doi.org/10.1016/j.cpr.2012.02.002 New Site Icon

Source:

Clin Psychol Rev. 2012; 32(4):301-315.

[PDF-454.06 KB]

Details:

Personal Authors:

Morris, Matthew C. ; Compas, Bruce E. ; Garber, Judy ;

Keywords:

[+]

Pubmed ID:

22459791

Pubmed Central ID:

PMC3340453

Description:

Exposure to traumatic stress is associated with increased risk for posttraumatic stress disorder (PTSD) and alterations of hypothalamic-pituitary-adrenocortical (HPA) function. Research linking traumatic stress with HPA function in PTSD has been inconsistent, however, in part due to (a) the inclusion of trauma-exposed individuals without PTSD (TE) in control groups and (b) a failure to consider comorbid major depressive disorder (MDD) and moderating variables. This meta-analysis of 47 studies (123 effect sizes, N=6008 individuals) revealed that daily cortisol output was lower for PTSD (d=-.36, SE=.15, p=.008) and PTSD+MDD (d=-.65, SE=.25, p=.008) groups relative to no trauma controls (NTC); TE and NTC groups did not differ significantly from each other. Afternoon/evening cortisol was lower in TE (d=-.25, SE=.09, p=.007) and PTSD (d=-.27, SE=.12, p=.021) groups and higher in PTSD+MDD groups (d=.49, SE=.24, p=.041) relative to NTC. Post-DST cortisol levels were lower in PTSD (d=-.40, SE=.12, p<.001), PTSD+MDD (d=-.65, SE=.14, p<.001), and TE groups (d=-.53, SE=.14, p<.001) relative to NTC. HPA effect sizes were moderated by age, sex, time since index event, and developmental timing of trauma exposure. These findings suggest that enhanced HPA feedback function may be a marker of trauma-exposure rather than a specific mechanism of vulnerability for PTSD, whereas lower daily cortisol output may be associated with PTSD in particular.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Main Document Checksum:

[+]

Supporting Files:

	nihms356790f3.jpg	image/jpeg
	NIHMS356790-supplement-01.zip	application/zip
	NIHMS356790-supplement-02.doc	application/msword
	nihms356790.nxml	application/octet-stream
	nihms356790f1.gif	image/gif
	nihms356790f1.jpg	image/jpeg
	nihms356790f2.gif	image/gif
	nihms356790f2.jpg	image/jpeg
	nihms356790f3.gif	image/gif

No Related Documents.

You May Also Like:

Gene expression associated with PTSD in World Trade Center responders: An RNA sequencing study

Personal Author:

Kuan, Pei-Fen; Waszczuk, Monika A.; Kotov, Roman; Clouston, Sean; Yang, Xiaohua; Singh, Prashant K.; Glenn, Sean T.; Cortes Gomez, Eduardo; Wang, Jianmin; Bromet, Evelyn; Luft, Benjamin J.;

Published:

Dec 18 2017

Source:

Transl Psychiatry. 7(12).

Description:

The gene expression approach has provided promising insights into the pathophysiology of posttraumatic stress disorder (PTSD). However, few studies used hypothesis-free transcriptome-wide approach to comprehensively understand gene expression underpi...

File Type:

[PDF - 884.01 KB]
Posttraumatic Stress Disorder: A Metabolic Disorder in Disguise?

Personal Author:

Michopoulos, Vasiliki; Vester, Aimee; Neigh, Gretchen;

Published:

May 28 2016

Source:

Exp Neurol. 284(Pt B):220-229

Description:

Posttraumatic stress disorder (PTSD) is a heterogeneous psychiatric disorder that affects individuals exposed to trauma and is highly co-morbid with other adverse health outcomes, including cardiovascular disease and obesity. The unique pathophysiolo...

File Type:

[PDF - 534.97 KB]
The maternal brain and its plasticity in humans

Personal Author:

Kim, Pilyoung; Strathearn, Lane; Swain, James E.;

Published:

Aug 09 2015

Source:

Horm Behav. 77:113-123

Description:

This article is part of a Special Issue "Parental Care". Early mother-infant relationships play important roles in infants' optimal development. New mothers undergo neurobiological changes that support developing mother-infant relationships regardles...

File Type:

[PDF - 537.59 KB]
The role of modifiable health-related behaviors in the association between PTSD and respiratory illness

Personal Author:

Waszczuk, Monika A; Ruggero, Camilo; Li, Kaiqiao; Luft, Benjamin J; Kotov, Roman;

Published:

November 01 2018

Source:

Behav Res Ther. 115:64-72

Description:

Background. : Posttraumatic stress disorder (PTSD) increases risk of future respiratory illness. However, mechanisms that underpin the association between these common and debilitating conditions remain unknown. The aim of this study was to identify ...

Public Access
Available on:

April 01, 2020
Implications of the Research Domain Criteria Project for Childhood Anxiety and its Disorders

Personal Author:

Lebowitz, Eli R.; Gee, Dylan G.; Pine, Daniel S.; Silverman, Wendy K.;

Published:

January 31 2018

Source:

Clin Psychol Rev. 64:99-109

Description:

Anxiety disorders are among the most prevalent psychiatric disorders in youth; however, progress in treatment for childhood anxiety has stalled over the past decade. The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) proje...

File Type:

[PDF - 116.09 KB]