Details:

Alternative Title:
Clin Psychol Rev
Personal Author:
Morris, Matthew C. ; Compas, Bruce E. ; Garber, Judy ;
Morris, Matthew C. ; Compas, Bruce E. ; Garber, Judy ; Less -
Description:
Exposure to traumatic stress is associated with increased risk for posttraumatic stress disorder (PTSD) and alterations of hypothalamic-pituitary-adrenocortical (HPA) function. Research linking traumatic stress with HPA function in PTSD has been inconsistent, however, in part due to (a) the inclusion of trauma-exposed individuals without PTSD (TE) in control groups and (b) a failure to consider comorbid major depressive disorder (MDD) and moderating variables. This meta-analysis of 47 studies (123 effect sizes, N=6008 individuals) revealed that daily cortisol output was lower for PTSD (d=-.36, SE=.15, p=.008) and PTSD+MDD (d=-.65, SE=.25, p=.008) groups relative to no trauma controls (NTC); TE and NTC groups did not differ significantly from each other. Afternoon/evening cortisol was lower in TE (d=-.25, SE=.09, p=.007) and PTSD (d=-.27, SE=.12, p=.021) groups and higher in PTSD+MDD groups (d=.49, SE=.24, p=.041) relative to NTC. Post-DST cortisol levels were lower in PTSD (d=-.40, SE=.12, p<.001), PTSD+MDD (d=-.65, SE=.14, p<.001), and TE groups (d=-.53, SE=.14, p<.001) relative to NTC. HPA effect sizes were moderated by age, sex, time since index event, and developmental timing of trauma exposure. These findings suggest that enhanced HPA feedback function may be a marker of trauma-exposure rather than a specific mechanism of vulnerability for PTSD, whereas lower daily cortisol output may be associated with PTSD in particular.
Subject:
[+]
Article
Circadian Rhythm
Comorbidity
Cortisol
Depression
Depressive Disorder, Major
Dexamethasone
Female
Humans
Hydrocortisone
Hypothalamo-Hypophyseal System
Male
Pituitary-Adrenal System
PTSD
Stress Disorders, Post-Traumatic
Trauma

Source:
Clin Psychol Rev. 2012; 32(4):301-315
Pubmed ID:
22459791
Pubmed Central ID:
PMC3340453
Document Type:
Journal Article ;
Funding:
R01 MH069940/MH/NIMH NIH HHS/United States ; UL1 RR024975-01/RR/NCRR NIH HHS/United States ; R01 MH068391-06/MH/NIMH NIH HHS/United States ; R01 MH064735/MH/NIMH NIH HHS/United States ; 1 F31 MH084425-01A1/MH/NIMH NIH HHS/United States ; ... More +
R01 MH069940/MH/NIMH NIH HHS/United States ; UL1 RR024975-01/RR/NCRR NIH HHS/United States ; R01 MH068391-06/MH/NIMH NIH HHS/United States ; R01 MH064735/MH/NIMH NIH HHS/United States ; 1 F31 MH084425-01A1/MH/NIMH NIH HHS/United States ; F31 MH084425-01A1/MH/NIMH NIH HHS/United States ; RC1MH088329/MH/NIMH NIH HHS/United States ; T32MH18921/MH/NIMH NIH HHS/United States ; G12 RR003032/RR/NCRR NIH HHS/United States ; TL1 RR024978/RR/NCRR NIH HHS/United States ; KL2 RR024977/RR/NCRR NIH HHS/United States ; R01MH64735/MH/NIMH NIH HHS/United States ; F31 MH084425/MH/NIMH NIH HHS/United States ; T32 MH018921/MH/NIMH NIH HHS/United States ; 1 UL1RR024975/RR/NCRR NIH HHS/United States ; R01 MH069940-05/MH/NIMH NIH HHS/United States ; R01 DA017805/DA/NIDA NIH HHS/United States ; UL1RR024975-01/RR/NCRR NIH HHS/United States ; R01HM069940/HM/NCHM CDC HHS/United States ; R01 MH068391/MH/NIMH NIH HHS/United States ; UL1 RR024975/RR/NCRR NIH HHS/United States ; R01 MH064735-04/MH/NIMH NIH HHS/United States ; RC1 MH088329-02/MH/NIMH NIH HHS/United States ; RC1 MH088329/MH/NIMH NIH HHS/United States ; R01MH068391/MH/NIMH NIH HHS/United States ; T32 MH018921-20/MH/NIMH NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:51b468a9d53091ab61e1f1b4efd5f8f5d224589f18900d021a9122f28de3c3f5
File Type:

Supporting Files

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  	NIHMS356790-supplement-01.zip	zip
  	NIHMS356790-supplement-02.doc	doc
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