Perspectives on Cell Reprogramming with RNA

Details

• Alternative Title:
  Trends Biotechnol
• Personal Author:
  Sul, Jai-Yoon ; Kim, Tae Kyung ; Lee, Jae Hee ; Eberwine, James
• Description:
  Recent advances in cell reprogramming have permitted the development of different stem cell lines and specific differentiated cell types using distinct technologies. Cell reprogramming is largely mediated by DNA and RNA. In this review, we explore the RNA-mediated cell reprogramming to induce specific target cell generation including stem cells, brain cells and cardiac cells. The ability of RNA populations to produce direct cell to cell phenotypic conversion is called Transcriptome Induced PhenotypeRemodeling (TIPeR). The theory and utility of RNA use for cellular reprogramming is explored in this review.
• Subjects:
  Animals Cell Differentiation Cell Physiological Phenomena DNA Gene Expression Regulation Humans
• Source:
  Trends Biotechnol. 2012; 30(5):243-249.
• Pubmed ID:
  22459515
• Pubmed Central ID:
  PMC3335965
• Document Type:
  Journal Article
• Funding:
  DP004117/DP/NCCDPHP CDC HHS/United States ; DP1 OD004117/OD/NIH HHS/United States ; DP1 OD004117-05/OD/NIH HHS/United States
• Volume:
  30
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:390c8792da1f18bbfd9cbecd97b53ddb1c49b4be711d3a460a30f3c35c2a39e5
• Download URL:
  https://stacks.cdc.gov/view/cdc/33350/cdc_33350_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]