Details:

Alternative Title:
Pediatr Infect Dis J
Publisher's site:
http://dx.doi.org/10.1097/INF.0b013e31824d9bd9
Personal Author:
Taha, Taha E. ; Dadabhai, Sufia S. ; Rahman, M. Hafizur ; Sun, Jin ; Kumwenda, Johnstone ; ... More +
Taha, Taha E. ; Dadabhai, Sufia S. ; Rahman, M. Hafizur ; Sun, Jin ; Kumwenda, Johnstone ; Kumwenda, Newton I. Less -
Description:
Background

We analyzed birth outcomes among infants of treatment-naïve, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi.

Methods

Data from six prospective studies at one research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA<37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from earlier studies (1989-94) and later studies (2000-07) are presented separately.

Results

The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% CI) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67 (0.48-0.95)) and PT birth (AOR 0.70 (0.51-0.95)) and later birth year was associated with lower odds of PT birth (AOR 0.35 (0.19-0.70)).

Conclusions

BW and GA remained stable within each time period. This analysis provides important baseline information for monitoring HIV treatment effects on birth outcomes. Modifiable factors affecting BW and GA should continue to be explored.


Subject:
[+]
Adult
Article
Birth Weight
Female
Gestational Age
HIV Infections
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Infectious Disease Transmission, Vertical
Male
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Outcome
Prospective Studies
Risk Factors
Young Adult

Source:
Pediatr Infect Dis J. 31(5):481-486.
Pubmed ID:
22327871
Pubmed Central ID:
PMC3329585
Document Type:
Journal Article
Funding:
#5R03TW01199/TW/FIC NIH HHS/United States ; 5-U50-PS022061-05/PS/NCHHSTP CDC HHS/United States ; N01-AI-35173-117/AI/NIAID NIH HHS/United States ; N01-CP-33005/CP/NCI NIH HHS/United States ; P01-AI-26499/AI/NIAID NIH HHS/United States ; ... More +
#5R03TW01199/TW/FIC NIH HHS/United States ; 5-U50-PS022061-05/PS/NCHHSTP CDC HHS/United States ; N01-AI-35173-117/AI/NIAID NIH HHS/United States ; N01-CP-33005/CP/NCI NIH HHS/United States ; P01-AI-26499/AI/NIAID NIH HHS/United States ; R03 TW001199/TW/FIC NIH HHS/United States ; R03 TW001199-01/TW/FIC NIH HHS/United States ; R03 TW001199-01S1/TW/FIC NIH HHS/United States ; R03 TW001199-02/TW/FIC NIH HHS/United States ; R03 TW001199-03/TW/FIC NIH HHS/United States ; R03 TW001199-04/TW/FIC NIH HHS/United States ; R03 TW001199-05/TW/FIC NIH HHS/United States ; R03 TW001199-06/TW/FIC NIH HHS/United States ; R21-AI-33874-01/AI/NIAID NIH HHS/United States ; R24 HD042854/HD/NICHD NIH HHS/United States ; U01 AI048005/AI/NIAID NIH HHS/United States ; U01 AI048005-01/AI/NIAID NIH HHS/United States ; U01 AI048005-02/AI/NIAID NIH HHS/United States ; U01 AI048005-03/AI/NIAID NIH HHS/United States ; U01 AI048005-04/AI/NIAID NIH HHS/United States ; U01 AI048005-05/AI/NIAID NIH HHS/United States ; U01 AI048005-05S1/AI/NIAID NIH HHS/United States ; U01 AI048005-05S2/AI/NIAID NIH HHS/United States ; U01 AI048005-05S3/AI/NIAID NIH HHS/United States ; U01 AI048005-05S4/AI/NIAID NIH HHS/United States ; U01-AI-48005/AI/NIAID NIH HHS/United States ; U50-CC0222061/CC/ODCDC CDC HHS/United States Less -
Place as Subject:
Malawi
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2ab24f33366b0ce2bff16f4e457a43789be5edaa811827e2d17d7b31b2700fb3
File Type:

Supporting Files

• 	NIHMS361114-supplement-1.ppt	ppt
  	nihms361114.nxml	txt
  	nihms361114f1.gif	gif
  	nihms361114f1.jpg	jpeg

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