Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Taha, Taha E. ; Dadabhai, Sufia S. ; Rahman, M. Hafizur ; Sun, Jin ; Kumwenda, Johnstone ; Kumwenda, Newton I.
• Description:
  Background
  
  We analyzed birth outcomes among infants of treatment-naïve, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi.
  
  Methods
  
  Data from six prospective studies at one research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA<37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from earlier studies (1989-94) and later studies (2000-07) are presented separately.
  
  Results
  
  The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% CI) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67 (0.48-0.95)) and PT birth (AOR 0.70 (0.51-0.95)) and later birth year was associated with lower odds of PT birth (AOR 0.35 (0.19-0.70)).
  
  Conclusions
  
  BW and GA remained stable within each time period. This analysis provides important baseline information for monitoring HIV treatment effects on birth outcomes. Modifiable factors affecting BW and GA should continue to be explored.
  
  
• Subjects:
  Adult Article Birth Weight Female Gestational Age HIV Infections Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Infant, Premature, Diseases Infectious Disease Transmission, Vertical Male Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome Prospective Studies Risk Factors Young Adult

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• Source:
  Pediatr Infect Dis J. 31(5):481-486.
• Pubmed ID:
  22327871
• Pubmed Central ID:
  PMC3329585
• Document Type:
  Journal Article
• Funding:
  #5R03TW01199/TW/FIC NIH HHS/United States ; 5-U50-PS022061-05/PS/NCHHSTP CDC HHS/United States ; N01-AI-35173-117/AI/NIAID NIH HHS/United States ; N01-CP-33005/CP/NCI NIH HHS/United States ; P01-AI-26499/AI/NIAID NIH HHS/United States ; R03 TW001199/TW/FIC NIH HHS/United States ; R03 TW001199-01/TW/FIC NIH HHS/United States ; R03 TW001199-01S1/TW/FIC NIH HHS/United States ; R03 TW001199-02/TW/FIC NIH HHS/United States ; R03 TW001199-03/TW/FIC NIH HHS/United States ; R03 TW001199-04/TW/FIC NIH HHS/United States ; R03 TW001199-05/TW/FIC NIH HHS/United States ; R03 TW001199-06/TW/FIC NIH HHS/United States ; R21-AI-33874-01/AI/NIAID NIH HHS/United States ; R24 HD042854/HD/NICHD NIH HHS/United States ; U01 AI048005/AI/NIAID NIH HHS/United States ; U01 AI048005-01/AI/NIAID NIH HHS/United States ; U01 AI048005-02/AI/NIAID NIH HHS/United States ; U01 AI048005-03/AI/NIAID NIH HHS/United States ; U01 AI048005-04/AI/NIAID NIH HHS/United States ; U01 AI048005-05/AI/NIAID NIH HHS/United States ; U01 AI048005-05S1/AI/NIAID NIH HHS/United States ; U01 AI048005-05S2/AI/NIAID NIH HHS/United States ; U01 AI048005-05S3/AI/NIAID NIH HHS/United States ; U01 AI048005-05S4/AI/NIAID NIH HHS/United States ; U01-AI-48005/AI/NIAID NIH HHS/United States ; U50-CC0222061/CC/ODCDC CDC HHS/United States
• Place as Subject:
  Malawi
• Volume:
  31
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2ab24f33366b0ce2bff16f4e457a43789be5edaa811827e2d17d7b31b2700fb3
• Download URL:
  https://stacks.cdc.gov/view/cdc/33345/cdc_33345_DS1.pdf
• File Type:
  [PDF - 362.13 KB ]