A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods1

Parra, Zuly E.; Mitchell, Kevin; Dalloul, Rami A.; Miller, Robert D.

Search our Collections

- Add this to...

A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods1

Published Date:

Mar 09 2012

Source:

J Immunol. 188(8):3912-3919.

Language:

English

[PDF-1.61 MB]

Details:

Alternative Title:

J Immunol

Personal Author:

Parra, Zuly E. ; Mitchell, Kevin ; Dalloul, Rami A. ; Miller, Robert D. ;

Description:

Analyses of the available avian genomes revealed the presence of a second TCRδ locus in the Galliformes. This second TCRδ locus is nonsyntenic to the conventional TCRα/δ and is unusual in that the V genes are more related to IgH V genes (VH) than to TCR V genes. The second TCRδ is not found in another avian lineage, the passerine zebra finch. Rather the finch's conventional TCRα/δ locus contains VH genes that are expressed with the conventional Cδ gene, similar to what has been found in amphibians. A comparison between Galliformes and Passeriformes genomic organization suggests an origin of the second TCRδ in the former lineage involving gene duplication. Expression of these atypical TCRδ transcripts with a VH domain paired with Cδ was found in lymphoid tissues of both avian lineages. The configuration of the second TCRδ in chicken and turkey is reminiscent of the TCRδ duplication that is present in nonplacental mammals and provides insight into the origin of the uniquely mammalian TCRμ locus.

Subject:

[+]

Pubmed ID:

22407916

Pubmed Central ID:

PMC3324631

Document Type:

Journal Article

Funding:

P20 GM103452/GM/NIGMS NIH HHS/United States ; P20 GM103452-09/GM/NIGMS NIH HHS/United States ; P20 RR018754/RR/NCRR NIH HHS/United States ; IP20RR18754/IP/NCIRD CDC HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	nihms358002f4.gif	image/gif
	nihms358002f4.jpg	image/jpeg
	nihms358002f5.gif	image/gif
	nihms358002f5.jpg	image/jpeg
	nihms358002f6.gif	image/gif
	nihms358002f6.jpg	image/jpeg
	nihms358002f7.gif	image/gif
	nihms358002f7.jpg	image/jpeg
	NIHMS358002-supplement-1.pdf	application/pdf
	nihms358002.nxml	text/xml
	nihms358002f1.gif	image/gif
	nihms358002f1.jpg	image/jpeg
	nihms358002f2.gif	image/gif
	nihms358002f2.jpg	image/jpeg
	nihms358002f3.gif	image/gif
	nihms358002f3.jpg	image/jpeg

No Related Documents.

A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods1

Search our Collections

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC