Details:

Alternative Title:
J Immunol
Personal Author:
Parra, Zuly E. ; Mitchell, Kevin ; Dalloul, Rami A. ; Miller, Robert D.
Parra, Zuly E. ; Mitchell, Kevin ; Dalloul, Rami A. ; Miller, Robert D. Less -
Description:
Analyses of the available avian genomes revealed the presence of a second TCRδ locus in the Galliformes. This second TCRδ locus is nonsyntenic to the conventional TCRα/δ and is unusual in that the V genes are more related to IgH V genes (VH) than to TCR V genes. The second TCRδ is not found in another avian lineage, the passerine zebra finch. Rather the finch's conventional TCRα/δ locus contains VH genes that are expressed with the conventional Cδ gene, similar to what has been found in amphibians. A comparison between Galliformes and Passeriformes genomic organization suggests an origin of the second TCRδ in the former lineage involving gene duplication. Expression of these atypical TCRδ transcripts with a VH domain paired with Cδ was found in lymphoid tissues of both avian lineages. The configuration of the second TCRδ in chicken and turkey is reminiscent of the TCRδ duplication that is present in nonplacental mammals and provides insight into the origin of the uniquely mammalian TCRμ locus.
Subjects:
[+]
Amino Acid Sequence Animals Article Evolution, Molecular Galliformes Gene Duplication Genes, T-Cell Receptor Genes, T-Cell Receptor Delta Genetic Loci Genome Genomics Molecular Sequence Data Passeriformes Phylogeny Sequence Alignment
Source:
J Immunol. 188(8):3912-3919
Pubmed ID:
22407916
Pubmed Central ID:
PMC3324631
Document Type:
Journal Article
Funding:
P20 GM103452/GM/NIGMS NIH HHSUnited States/ ; P20 GM103452-09/GM/NIGMS NIH HHSUnited States/ ; P20 RR018754/RR/NCRR NIH HHSUnited States/ ; IP20RR18754/IP/NCIRD CDC HHSUnited States/
P20 GM103452/GM/NIGMS NIH HHSUnited States/ ; P20 GM103452-09/GM/NIGMS NIH HHSUnited States/ ; P20 RR018754/RR/NCRR NIH HHSUnited States/ ; IP20RR18754/IP/NCIRD CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:73a7061084037459c311cc66b0545bef3670825bc7358fab8fd500d9d2c660ff
Download URL:
https://stacks.cdc.gov/view/cdc/33341/cdc_33341_DS1.pdf
File Type:

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