Details:

Alternative Title:
ACS Nano
Publisher's site:
http://dx.doi.org/10.1021/nn202201j
Personal Author:
Tyurina, Yulia Y. ; Kisin, Elena R. ; Murray, Ashley ; Tyurin, Vladimir A. ; Kapralova, Valentina I. ; ... More +
Tyurina, Yulia Y. ; Kisin, Elena R. ; Murray, Ashley ; Tyurin, Vladimir A. ; Kapralova, Valentina I. ; Sparvero, Louis J. ; Amoscato, Andrew A. ; Samhan-Arias, Alejandro K. ; Swedin, Linda ; Lahesmaa, Riitta ; Fadeel, Bengt ; Shvedova, Anna A. ; Kagan, Valerian E. ; Less -
Description:
It is commonly believed that nanomaterials cause nonspecific oxidative damage. Our mass spectrometry-based oxidative lipidomics analysis of all major phospholipid classes revealed highly selective patterns of pulmonary peroxidation after inhalation exposure of mice to single-walled carbon nanotubes. No oxidized molecular species were found in the two most abundant phospholipid classes: phosphatidylcholine and phosphatidylethanolamine. Peroxidation products were identified in three relatively minor classes of anionic phospholipids, cardiolipin, phosphatidylserine, and phosphatidylinositol, whereby oxygenation of polyunsaturated fatty acid residues also showed unusual substrate specificity. This nonrandom peroxidation coincided with the accumulation of apoptotic cells in the lung. A similar selective phospholipid peroxidation profile was detected upon incubation of a mixture of total lung lipids with H(2)O(2)/cytochrome c known to catalyze cardiolipin and phosphatidylserine peroxidation in apoptotic cells. The characterized specific phospholipid peroxidation signaling pathways indicate new approaches to the development of mitochondria-targeted regulators of cardiolipin peroxidation to protect against deleterious effects of pro-apoptotic effects of single-walled carbon nanotubes in the lung.
Subject:
[+]
Animals
Apoptosis
Article
Bronchoalveolar Lavage Fluid
Cardiolipin Oxidation
Lipidomics
Lipid Peroxidation
Lipids
Lung
Mice
Mice, Inbred C57BL
Mouse Lung
Nanotubes, Carbon
Oxidative Lipidomics
Phosphatidylserine Oxidation
Phosphoproteins
Proteomics
Single Walled Carbon Nanotubes

Source:
ACS Nano. 5(9):7342-7353. ;
Pubmed ID:
21800898
Pubmed Central ID:
PMC3321726
Document Type:
Journal Article ;
Funding:
HL094488/HL/NHLBI NIH HHS/United States ; HL70755/HL/NHLBI NIH HHS/United States ; OH008282/OH/NIOSH CDC HHS/United States ; R01 HL070755/HL/NHLBI NIH HHS/United States ; R01 HL070755-06/HL/NHLBI NIH HHS/United States ; ... More +
HL094488/HL/NHLBI NIH HHS/United States ; HL70755/HL/NHLBI NIH HHS/United States ; OH008282/OH/NIOSH CDC HHS/United States ; R01 HL070755/HL/NHLBI NIH HHS/United States ; R01 HL070755-06/HL/NHLBI NIH HHS/United States ; R01 HL094488/HL/NHLBI NIH HHS/United States ; R01 HL094488-02/HL/NHLBI NIH HHS/United States ; U19 AI068021/AI/NIAID NIH HHS/United States ; U19 AI068021-07/AI/NIAID NIH HHS/United States ; U19AIO68021/PHS HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ca6ac721c9ba95bbcf8b272d03c80f58247b57518ae8e8f30e3f02f104ff0e05
File Type:

Supporting Files

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