Details:

Alternative Title:
ACS Nano
Publisher's site:
http://dx.doi.org/10.1021/nn202201j
Personal Author:
Tyurina, Yulia Y. ; Kisin, Elena R. ; Murray, Ashley ; Tyurin, Vladimir A. ; Kapralova, Valentina I. ; ... More +
Tyurina, Yulia Y. ; Kisin, Elena R. ; Murray, Ashley ; Tyurin, Vladimir A. ; Kapralova, Valentina I. ; Sparvero, Louis J. ; Amoscato, Andrew A. ; Samhan-Arias, Alejandro K. ; Swedin, Linda ; Lahesmaa, Riitta ; Fadeel, Bengt ; Shvedova, Anna A. ; Kagan, Valerian E. Less -
Description:
It is commonly believed that nanomaterials cause nonspecific oxidative damage. Our mass spectrometry-based oxidative lipidomics analysis of all major phospholipid classes revealed highly selective patterns of pulmonary peroxidation after inhalation exposure of mice to single-walled carbon nanotubes. No oxidized molecular species were found in the two most abundant phospholipid classes: phosphatidylcholine and phosphatidylethanolamine. Peroxidation products were identified in three relatively minor classes of anionic phospholipids, cardiolipin, phosphatidylserine, and phosphatidylinositol, whereby oxygenation of polyunsaturated fatty acid residues also showed unusual substrate specificity. This nonrandom peroxidation coincided with the accumulation of apoptotic cells in the lung. A similar selective phospholipid peroxidation profile was detected upon incubation of a mixture of total lung lipids with H(2)O(2)/cytochrome c known to catalyze cardiolipin and phosphatidylserine peroxidation in apoptotic cells. The characterized specific phospholipid peroxidation signaling pathways indicate new approaches to the development of mitochondria-targeted regulators of cardiolipin peroxidation to protect against deleterious effects of pro-apoptotic effects of single-walled carbon nanotubes in the lung.
Subjects:
[+]
Animals Bronchoalveolar Lavage Fluid Lipid Peroxidation Lipids Lung Mice Mice, Inbred C57BL Nanotubes, Carbon Phosphoproteins Proteomics
Source:
ACS Nano. 5(9):7342-7353
Pubmed ID:
21800898
Pubmed Central ID:
PMC3321726
Document Type:
Journal Article
Funding:
R01 HL070755/HL/NHLBI NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; U19 AI068021/AI/NIAID NIH HHSUnited States/ ; U19AIO68021/PHS HHSUnited States/ ; R01 HL094488-02/HL/NHLBI NIH HHSUnited States/ ; ... More +
R01 HL070755/HL/NHLBI NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; U19 AI068021/AI/NIAID NIH HHSUnited States/ ; U19AIO68021/PHS HHSUnited States/ ; R01 HL094488-02/HL/NHLBI NIH HHSUnited States/ ; R01 HL094488/HL/NHLBI NIH HHSUnited States/ ; OH008282/OH/NIOSH CDC HHSUnited States/ ; HL70755/HL/NHLBI NIH HHSUnited States/ ; U19 AI068021-07/AI/NIAID NIH HHSUnited States/ ; R01 HL070755-06/HL/NHLBI NIH HHSUnited States/ ; HL094488/HL/NHLBI NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ca6ac721c9ba95bbcf8b272d03c80f58247b57518ae8e8f30e3f02f104ff0e05
Download URL:
https://stacks.cdc.gov/view/cdc/33335/cdc_33335_DS1.pdf
File Type:

Supporting Files

• 	nihms-316605-f0005.gif	gif
  	nihms-316605-f0005.jpg	jpeg
  	nihms-316605-f0006.gif	gif
  	nihms-316605-f0006.jpg	jpeg
  	nihms-316605.nxml	xml
  	NIHMS316605-supplement-1_si_001.pdf	pdf
  	nihms-316605-f0001.gif	gif
  	nihms-316605-f0001.jpg	jpeg
  	nihms-316605-f0002.gif	gif
  	nihms-316605-f0002.jpg	jpeg
  	nihms-316605-f0003.gif	gif
  	nihms-316605-f0003.jpg	jpeg
  	nihms-316605-f0004.gif	gif
  	nihms-316605-f0004.jpg	jpeg

More +