Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Friesen, Melissa C ; Costello, Sadie ; Thurston, Sally W ; Eisen, Ellen A
• Description:
  Background
  
  Metalworking fluids (MWF) — straight, soluble, and synthetic — have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence.
  
  Methods
  
  An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k=0–1.
  
  Results
  
  For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k=0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin.
  
  Conclusions
  
  Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.
  
  
• Subjects:
  Automobiles Cohort Studies Disinfectants Endotoxins Female Humans Incidence Male Metals Michigan Neoplasms Nitrosamines Occupational Exposure Petroleum Polycyclic Aromatic Hydrocarbons Registries Risk Assessment Time Factors Water

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• Keywords:
  Biocides Cancer Incidence Chlorination Cohort Study Endotoxin Household Water Treatment Metalworking Fluids Safe Water Storage
• Source:
  Am J Ind Med. 54(6):450-460
• Pubmed ID:
  21328414
• Pubmed Central ID:
  PMC3301446
• Document Type:
  Journal Article
• Funding:
  UL1 RR024160-04/RR/NCRR NIH HHSUnited States/ ; R01OH008927/OH/NIOSH CDC HHSUnited States/ ; R01 OH008927/OH/NIOSH CDC HHSUnited States/ ; UL1 RR024160/RR/NCRR NIH HHSUnited States/ ; UL1RR024160/RR/NCRR NIH HHSUnited States/
• Volume:
  54
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f3fe620831cd5866f08056ec4f2b84f2c4e66fc6c4ca6d6933e1b463306130d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/33324/cdc_33324_DS1.pdf
• File Type:
  [PDF - 824.34 KB ]