A Closer Look at Depression and Its Relationship to HIV Antiretroviral Adherence

Details

• Alternative Title:
  Ann Behav Med
• Personal Author:
  Wagner, Glenn J. ; Goggin, Kathy ; Remien, Robert H. ; Rosen, Marc I. ; Simoni, Jane ; Bangsberg, David R. ; Liu, Honghu
• Description:
  Background
  
  Depression consistently predicts nonadherence to human immunodeficiency virus (HIV) antiretroviral therapy, but which aspects of depression are most influential is unknown. Such knowledge could inform assessments of adherence readiness and the type of depression treatment to utilize.
  
  Purpose
  
  We examined how depression severity, symptom type and change over time relate to adherence.
  
  Methods
  
  Microelectronic adherence and self-reported depression data from 1374 participants across merged studies were examined with cross-sectional and longitudinal analyses. Depression variables included a continuous measure, categorical measure of severity, cognitive and vegetative subscales, and individual symptoms.
  
  Results
  
  At baseline, mean adherence was 69%, and 25% had mild/moderate and 18% had severe depression. In cross-sectional multivariate analyses, continuous depression, cognitive depressive symptoms and severe depression were associated with lower adherence. In longitudinal analysis, reductions in both continuous and categorical depression predicted increased adherence.
  
  Conclusions
  
  The relationship between global continuous depression and nonadherence was statistically significant, but relatively weak compared to that of cognitive depressive symptoms and severe depression, which appear to pose strong challenges to adherence and call for the need for early detection and treatment of depression.
  
  
• Subjects:
  Adolescent Adult Aged Anti-Retroviral Agents Antiretroviral Therapy, Highly Active Cognition Disorders Cross-Sectional Studies Depression Female HIV Infections Humans Longitudinal Studies Male Medication Adherence Middle Aged Regression Analysis Severity Of Illness Index Socioeconomic Factors Time Factors Young Adult

  More +
• Source:
  Ann Behav Med. 42(3):352-360.
• Pubmed ID:
  21818528
• Pubmed Central ID:
  PMC3226751
• Document Type:
  Journal Article
• Funding:
  AI069419/AI/NIAID NIH HHS/United States ; AI38858/AI/NIAID NIH HHS/United States ; CC02-SD-003/CC/ODCDC CDC HHS/United States ; CC99-SD003/CC/ODCDC CDC HHS/United States ; K02DA017277/DA/NIDA NIH HHS/United States ; K23MH01862/MH/NIMH NIH HHS/United States ; P01MH49548/MH/NIMH NIH HHS/United States ; R01 MH054907/MH/NIMH NIH HHS/United States ; R01 MH068197/MH/NIMH NIH HHS/United States ; R01 MH078773/MH/NIMH NIH HHS/United States ; R01 MH078773-01A1/MH/NIMH NIH HHS/United States ; R01AI41413/AI/NIAID NIH HHS/United States ; R01DA015679/DA/NIDA NIH HHS/United States ; R01DA11869/DA/NIDA NIH HHS/United States ; R01DA13826/DA/NIDA NIH HHS/United States ; R01DA15215/DA/NIDA NIH HHS/United States ; R01MH01584/MH/NIMH NIH HHS/United States ; R01MH078773/MH/NIMH NIH HHS/United States ; R01MH54907/MH/NIMH NIH HHS/United States ; R01MH58986/MH/NIMH NIH HHS/United States ; R01MH61173/MH/NIMH NIH HHS/United States ; R01MH61695/MH/NIMH NIH HHS/United States ; R01MH68197/MH/NIMH NIH HHS/United States ; R01NR04749/NR/NINR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  42
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:febdce310901b5c0b7ed939482c1b9d65d16f5f7509d1e34a6e822629278a4d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/33276/cdc_33276_DS1.pdf
• File Type:
  [PDF - 324.50 KB ]