Details:

Alternative Title:
ACS Nano
Personal Author:
Tkach, Alexey V. ; Shurin, Galina V. ; Shurin, Michael R. ; Kisin, Elena R. ; Murray, Ashley R. ; ... More +
Tkach, Alexey V. ; Shurin, Galina V. ; Shurin, Michael R. ; Kisin, Elena R. ; Murray, Ashley R. ; Young, Shih-Houng ; Star, Alexander ; Fadeel, Bengt ; Kagan, Valerian E. ; Shvedova, Anna A. Less -
Description:
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
Subjects:
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Animals Article Cell Count Dendritic Cells Female Immune System Immunosuppression Immunosuppressive Agents Lung Mice Nanoparticles Nanotubes Nanotubes, Carbon Pharynx Pneumonia Spleen T-Lymphocytes
Source:
ACS Nano. 5(7):5755-5762.
Pubmed ID:
21657201
Pubmed Central ID:
PMC3170729
Document Type:
Journal Article
Funding:
OH008282/OH/NIOSH CDC HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States ; R01 ES019304-02/ES/NIEHS NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States
OH008282/OH/NIOSH CDC HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States ; R01 ES019304-02/ES/NIEHS NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8333db0f46fd6593962ee03f6057ede502f6011f057131d41d33072d9416d1e9
Download URL:
https://stacks.cdc.gov/view/cdc/33244/cdc_33244_DS1.pdf
File Type:

Supporting Files

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