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Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure
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Published Date:Jun 15 2011
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Publisher's site:
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Source:ACS Nano. 5(7):5755-5762.
[PDF - 1.38 MB]
Details:
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Personal Authors:
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Keywords:
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Pubmed ID:21657201
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Pubmed Central ID:PMC3170729
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Funding:OH008282/OH/NIOSH CDC HHS/United States
R01 ES019304/ES/NIEHS NIH HHS/United States
R01 ES019304-02/ES/NIEHS NIH HHS/United States
R01ES019304/ES/NIEHS NIH HHS/United States
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Document Type:
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Collection(s):
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Description:Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naìˆve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
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Supporting Files:
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