Details:

Alternative Title:
ACS Nano
Publisher's site:
http://dx.doi.org/10.1021/nn2014479
Personal Author:
Tkach, Alexey V.; Shurin, Galina V.; Shurin, Michael R.; Kisin, Elena R.; Murray, Ashley R.; ... More +
Tkach, Alexey V.; Shurin, Galina V.; Shurin, Michael R.; Kisin, Elena R.; Murray, Ashley R.; Young, Shih-Houng; Star, Alexander; Fadeel, Bengt; Kagan, Valerian E.; Shvedova, Anna A.; Less -
Description:
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
Subject:
[+]
Animals
Article
Cell Count
Dendritic Cells
Female
Immune System
Immunosuppression
Immunosuppressive Agents
Lung
Mice
Nanoparticles
Nanotubes
Nanotubes, Carbon
Pharynx
Pneumonia
Spleen
T-Lymphocytes

Source:
ACS Nano. 5(7):5755-5762.;
Pubmed ID:
21657201
Pubmed Central ID:
PMC3170729
Document Type:
Journal Article;
Funding:
OH008282/OH/NIOSH CDC HHS/United States; R01 ES019304/ES/NIEHS NIH HHS/United States; R01 ES019304-02/ES/NIEHS NIH HHS/United States; R01ES019304/ES/NIEHS NIH HHS/United States;
OH008282/OH/NIOSH CDC HHS/United States; R01 ES019304/ES/NIEHS NIH HHS/United States; R01 ES019304-02/ES/NIEHS NIH HHS/United States; R01ES019304/ES/NIEHS NIH HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8333db0f46fd6593962ee03f6057ede502f6011f057131d41d33072d9416d1e9
File Type:

Supporting Files

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