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Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure
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  1. Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
    Personal Author:
    Swedin, Linda; Arrighi, Romanico; Andersson-Willman, Britta; Murray, Ashley; Chen, Yunying; Karlsson, Mikael C I; Georén, Susanna Kumlien; Tkach, Alexey V; Shvedova, Anna A; Fadeel, Bengt; Barragan, Antonio; Scheynius, Annika;
    Published Date:
    May 23 2012
    Source:
    Part Fibre Toxicol. 2012; 9:16.
    Description:
    BackgroundSingle-walled carbon nanotubes (SWCNT) trigger pronounced inflammation and fibrosis in the lungs of mice following administration via pharyngeal aspiration or inhalation. Human exposure to SWCNT in an occupational setting may occur in conju...
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  2. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress
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    Shvedova, Anna A.; Pietroiusti, Antonio; Fadeel, Bengt; Kagan, Valerian E.;
    Published Date:
    Apr 06 2012
    Source:
    Toxicol Appl Pharmacol. 261(2):121-133.
    Description:
    Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse ef...
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  3. Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo
    Personal Author:
    Konduru, Nagarjun V.; Tyurina, Yulia Y.; Feng, Weihong; Basova, Liana V.; Belikova, Natalia A.; Bayir, Hülya; Clark, Katherine; Rubin, Marc; Stolz, Donna; Vallhov, Helen; Scheynius, Annika; Witasp, Erika; Fadeel, Bengt; Kichambare, Padmakar D.; Star, Alexander; Kisin, Elena R.; Murray, Ashley R.; Shvedova, Anna A.; Kagan, Valerian E.;
    Published Date:
    Feb 09 2009
    Source:
    PLoS ONE. 2009; 4(2).
    Description:
    Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We re...
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  4. Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
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    Murray, Ashley R; Kisin, Elena R; Tkach, Alexey V; Yanamala, Naveena; Mercer, Robert; Young, Shih-Houng; Fadeel, Bengt; Kagan, Valerian E; Shvedova, Anna A;
    Published Date:
    Apr 10 2012
    Source:
    Part Fibre Toxicol. 2012; 9:10.
    Description:
    BackgroundCarbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurring asbestos fibers which are kn...
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  5. Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma
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    Shurin, Michael R.; Yanamala, Naveena; Kisin, Elena R.; Tkach, Alexey V.; Shurin, Galina V.; Murray, Ashley R.; Leonard, Howard D.; Reynolds, Jeffrey S.; Gutkin, Dmirtiy W.; Star, Alexander; Fadeel, Bengt; Savolainen, Kai; Kagan, Valerian E.; Shvedova, Anna A.;
    Published Date:
    May 23 2014
    Source:
    ACS Nano. 2014; 8(6):5585-5599.
    Description:
    Several lines of evidence indicate that exposure to nanoparticles (NPs) is able to modify airway immune responses, thus facilitating the development of respiratory diseases. Graphene oxide (GO) is a promising carbonaceous nanomaterial with unique phy...
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