Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

Details

• Alternative Title:
  ACS Nano
• Personal Author:
  Tkach, Alexey V. ; Shurin, Galina V. ; Shurin, Michael R. ; Kisin, Elena R. ; Murray, Ashley R. ; Young, Shih-Houng ; Star, Alexander ; Fadeel, Bengt ; Kagan, Valerian E. ; Shvedova, Anna A.
• Description:
  Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
• Subjects:
  Animals Cell Count Dendritic Cells Female Immunosuppressive Agents Lung Mice Nanotubes, Carbon Pharynx Pneumonia Spleen T-Lymphocytes

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• Source:
  ACS Nano. 5(7):5755-5762.
• Pubmed ID:
  21657201
• Pubmed Central ID:
  PMC3170729
• Document Type:
  Journal Article
• Funding:
  OH008282/OH/NIOSH CDC HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States ; R01 ES019304-02/ES/NIEHS NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States
• Volume:
  5
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8333db0f46fd6593962ee03f6057ede502f6011f057131d41d33072d9416d1e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/33244/cdc_33244_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]