Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

Tkach, Alexey V.; Shurin, Galina V.; Shurin, Michael R.; Kisin, Elena R.; Murray, Ashley R.; Young, Shih-Houng; Star, Alexander; Fadeel, Bengt; Kagan, Valerian E.; Shvedova, Anna A.

doi:10.1021/nn2014479

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Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

Published Date:

Jun 15 2011

Publisher's site:

http://dx.doi.org/10.1021/nn2014479

Source:

ACS Nano. 5(7):5755-5762.

[PDF-1.38 MB]

Details:

Alternative Title:

ACS Nano

Personal Author:

Tkach, Alexey V. ; Shurin, Galina V. ; Shurin, Michael R. ; Kisin, Elena R. ; Murray, Ashley R. ; ... More ▼

Description:

Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.

Subject:

[+]

Pubmed ID:

21657201

Pubmed Central ID:

PMC3170729

Document Type:

Journal Article

Funding:

OH008282/OH/NIOSH CDC HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States ; R01 ES019304-02/ES/NIEHS NIH HHS/United States ; R01ES019304/ES/NIEHS NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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