Race Disparities in Wilms Tumor Incidence and Biology
Published Date:Mar 31 2011
Source:J Surg Res. 2011; 170(1):112-119.
Keywords:African Continental Ancestry Group
European Continental Ancestry Group
Health Status Disparities
Imaging Mass Spectrometry
Race Disparities In Cancer
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Pubmed Central ID:PMC3150230
Funding:4R00CA135695-03/CA/NCI NIH HHS/United States
5T32CA106183-06A1/CA/NCI NIH HHS/United States
DP07-703 DP00822-04/DP/NCCDPHP CDC HHS/United States
P30-CA68485/CA/NCI NIH HHS/United States
R00 CA135695/CA/NCI NIH HHS/United States
R00 CA135695-03/CA/NCI NIH HHS/United States
T32 CA106183/CA/NCI NIH HHS/United States
T32 CA106183-06A1/CA/NCI NIH HHS/United States
UL1 RR024975/RR/NCRR NIH HHS/United States
Wilms tumor (WT) is thought to arise in children of black African ancestry with greater frequency than whites. To clarify the biological basis for race disparities in WT, we first verified that black children residing in Tennessee have an increased incidence of WT, and second, established molecular profiles in WT that are specific to race.
Materials and Methods
To assess race disparities in WT epidemiology, the Tennessee Cancer Registry (TCR) was queried for all in-state patients less than 20 years of age and registered between 1999–2008. To explore race disparities in WT biology, six black and four white WT specimens acquired in Tennessee were analyzed using imaging mass spectrometry (IMS).
TCR data show that black children are overrepresented among WT patients (29%) relative to all other childhood cancers (18.5%; p=0.01). WT ranked the 5th most common cancer diagnosis among blacks, but 9th among whites. The diagnosis of WT occurred 79% more frequently among blacks (n=28) than whites (n=69; p=0.01), and proportionally more blacks tended to present with distant disease. Although overall survival from WT was not statistically different between blacks (92.9%) and whites (94.0%), black males showed the lowest survival (85%; p=0.21). IMS analysis identified peptide spectra from both WT blastema and stroma that independently classify specimens according to race with greater than 80% accuracy.
In Tennessee, black children appear more susceptible than whites to develop WT. Race-specific molecular profiles can be determined that may help to clarify pathways of Wilms tumorigenesis and the biological basis for race disparities in WT incidence and biology.
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