Details:

Alternative Title:
Haemophilia
Publisher's site:
http://dx.doi.org/10.1111/j.1365-2516.2011.02501.x
Personal Author:
Ragni, Margaret V. ; Moore, Charity G.
Ragni, Margaret V. ; Moore, Charity G. Less -
Description:
Background

Atherosclerotic heart disease (ASHD) is a common cause of morbidity and mortality in Western society. Few studies have determined prevalence and predictors of ASHD in hemophilia (HA), a population whose survival is improving with safer blood products and effective treatments for AIDS and hepatitis C.

Objectives

The purpose of this study was to determine prevalence and factors associated with ASHD in hemophilia A patients in Pennsylvania.

Methods

The prevalence of ASHD (myocardial infarction, angina, coronary disease), cardiac catheterization, coronary angiography, co-morbidities, and in-hospital mortality were assessed on statewide ASHD discharge data, 2001–2006, from the Pennsylvania Health Care Cost Containment Council (PHC4).

Results

The prevalence of hemophilia ASHD admissions fluctuated between 6.5% and 10.5% for 2001 to 2006, p=0.62. Compared to HA without ASHD, HA with ASHD were older and more likely to be hypertensive, hyperlipidemic, and diabetic, all p<0.0001, with greater severity of illness, p=0.013. By contrast, HA and non-HA with ASHD had similar rates of hypertension, diabetes, and ICD-9 specified ischemic heart disease, including acute myocardial infarction (MI), p=0.39, old MI, p=0.47, and angina, p=0.63. Rates of catheterization and angiography, p=0.06 and p=0.07, were marginally lower, but primary circulatory system admitting diagnoses, p=0.29, were similar between HA and non-HA ASHD groups, as was length of stay, p=0.14, severity of illness, p=0.64, and in-hospital deaths, p=0.75.

Conclusions

Hemophilia patients with ASHD have similar cardiovascular risk factors, admitting diagnoses, severity of illness, and in-hospital mortality as the general population. These findings suggest cardiovascular prevention measures should be promoted in hemophilia.


Subject:
[+]
Adult
Aged
Age Factors
Atherosclerosis
Coronary Artery Disease
Hemophilia A
Hospitalization
Humans
Male
Middle Aged
Prevalence
Risk Factors

Source:
Haemophilia. 17(6):867-871.
Pubmed ID:
21371197
Pubmed Central ID:
PMC3134626
Document Type:
Journal Article
Funding:
#1-H-30-MC-00038-01/PHS HHS/United States ; U10DD000193/DD/NCBDD CDC HHS/United States ; UL-1 RR024153/RR/NCRR NIH HHS/United States ; UL1 RR024153/RR/NCRR NIH HHS/United States ; UL1 RR024153-04/RR/NCRR NIH HHS/United States ; ... More +
#1-H-30-MC-00038-01/PHS HHS/United States ; U10DD000193/DD/NCBDD CDC HHS/United States ; UL-1 RR024153/RR/NCRR NIH HHS/United States ; UL1 RR024153/RR/NCRR NIH HHS/United States ; UL1 RR024153-04/RR/NCRR NIH HHS/United States ; UL1 TR000005/TR/NCATS NIH HHS/United States Less -
Place as Subject:
Pennsylvania
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:deeb6918d3fc2d4f2b9af2a977cfd1b972e70c52b14032519a469d4758025514
File Type:

Supporting Files

• 	nihms-266316-f0001.gif	gif
  	nihms-266316-f0001.jpg	jpeg
  	nihms-266316.nxml	txt

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