Acute Decrease in HDL Cholesterol Associated With Exposure to Welding Fumes

Details

• Journal Article:
  J Occup Environ Med
• Personal Author:
  Rice, Mary B. ; Cavallari, Jennifer M. ; Fang, Shona ; Christiani, David C.
• Description:
  Objective
  
  To investigate acute changes in circulating lipids after exposure to relatively high levels of particulate matter through welding.
  
  Methods
  
  Using a repeated measures panel study, lipid levels before and after welding and personal exposures to fine particulate matter (PM2.5) were measured in 36 male welders over 63 exposure and/or control days.
  
  Results
  
  There was a trend toward decrease in HDL (−2.3 mg/dL, P = 0.08) 18 hours after welding. This effect became significant (−2.6 mg/dL, P = 0.05) after adjustment for possible confounders. The effect was strongest (−4.3 mg/dL, P = 0.02) among welders who did not weld the day before the study. There were no significant changes in other lipids associated with welding or PM2.5 exposure.
  
  Conclusion
  
  Welding exposure was associated with an acute decrease in circulating HDL, which may relate to the inflammatory and proatherosclerotic effects of fine particle exposure.
  
  
• Subjects:
  Air Pollutants, Occupational Cholesterol, HDL Chronic Disease Inhalation Exposure Occupational Exposure Occupational Health Particulate Matter Smoking Welding
• Keywords:
  Construction; Construction-workers; Welders; Welding; Welding-equipment; Fumes; Particulates; Lipids; Biological-monitoring; Men; Exposure-assessment; Exposure-levels; Metal-compounds; Metal-fumes
• Source:
  J Occup Environ Med. 2011; 53(1):17-21.
• Pubmed ID:
  21187793
• Pubmed Central ID:
  PMC3074942
• Document Type:
  Text
• Funding:
  ES00002/ES/NIEHS NIH HHS/United States ; ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860-09/ES/NIEHS NIH HHS/United States ; T32 ES 07069/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11 pdf pages
• Volume:
  53
• Issue:
  1
• NIOSHTIC Number:
  nn:20038766
• Federal Fiscal Year:
  2011
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:20aa1c27538a7b992ecdc0c47a4c560ee6b84ae04a6264b99d8ae5a9c76582968996643c25bd8d79d1fb79a2c9b3ea45bdcdc88df56cc7f0cb153d550647c0d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/33193/cdc_33193_DS1.pdf
• File Type:
  [PDF - 332.78 KB ]