Acute Decrease in HDL Cholesterol Associated With Exposure to Welding Fumes

Rice, Mary Berlik; Cavallari, Jenn; Fang, Shona; Christiani, David

doi:10.1097/JOM.0b013e3182028d20

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Acute Decrease in HDL Cholesterol Associated With Exposure to Welding Fumes

Published Date:

Jan 2011

Publisher's site:

http://dx.doi.org/10.1097/JOM.0b013e3182028d20 New Site Icon

Source:

J Occup Environ Med. 2011; 53(1):17-21.

[PDF - 332.78 KB]

Details:

Personal Authors:

Rice, Mary Berlik ; Cavallari, Jenn ; Fang, Shona ; Christiani, David ;

Keywords:

[+]

Pubmed ID:

21187793

Pubmed Central ID:

PMC3074942

Description:

Objective

To investigate acute changes in circulating lipids after exposure to relatively high levels of particulate matter through welding.

Methods

Using a repeated measures panel study, lipid levels before and after welding and personal exposures to fine particulate matter (PM2.5) were measured in 36 male welders over 63 exposure and/or control days.

Results

There was a trend toward decrease in HDL (−2.3 mg/dL, P = 0.08) 18 hours after welding. This effect became significant (−2.6 mg/dL, P = 0.05) after adjustment for possible confounders. The effect was strongest (−4.3 mg/dL, P = 0.02) among welders who did not weld the day before the study. There were no significant changes in other lipids associated with welding or PM2.5 exposure.

Conclusion

Welding exposure was associated with an acute decrease in circulating HDL, which may relate to the inflammatory and proatherosclerotic effects of fine particle exposure.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

ES00002/ES/NIEHS NIH HHS/United States
ES009860/ES/NIEHS NIH HHS/United States
R01 ES009860/ES/NIEHS NIH HHS/United States
R01 ES009860-09/ES/NIEHS NIH HHS/United States
T32 ES 07069/ES/NIEHS NIH HHS/United States
T42 OH008416/OH/NIOSH CDC HHS/United States

Supporting Files:

nihms280796.nxml

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