Acute Decrease in HDL Cholesterol Associated With Exposure to Welding Fumes

Details

• Journal Article:
  Journal of Occupational and Environmental Medicine
• Personal Author:
  Rice, Mary B. ; Cavallari, Jennifer M. ; Fang, Shona ; Christiani, David C.
• Description:
  OBJECTIVE: To investigate acute changes in circulating lipids after exposure to relatively high levels of particulate matter through welding. METHODS: Using a repeated measures panel study, lipid levels before and after welding and personal exposures to fine particulate matter (PM2.5) were measured in 36 male welders over 63 exposure and/or control days. RESULTS: There was a trend toward decrease in HDL (-2.3 mg/dL, P = 0.08) 18 hours after welding. This effect became significant (-2.6 mg/dL, P = 0.05) after adjustment for possible confounders. The effect was strongest (-4.3 mg/dL, P = 0.02) among welders who did not weld the day before the study. There were no significant changes in other lipids associated with welding or PM2.5 exposure. CONCLUSION: Welding exposure was associated with an acute decrease in circulating HDL, which may relate to the inflammatory and proatherosclerotic effects of fine particle exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cholesterol, HDL Chronic Disease Construction Industry Environmental Monitoring Inhalation Exposure Lipids Metals Occupational Exposure Occupational Health Particulate Matter Safety Smoking Welding

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• Keywords:
  Construction; Construction-workers; Welders; Welding; Welding-equipment; Fumes; Particulates; Lipids; Biological-monitoring; Men; Exposure-assessment; Exposure-levels; Metal-compounds; Metal-fumes
• Source:
  J Occup Environ Med 2011 Jan; 53(1):17-21
• ISSN:
  1076-2752
• Pubmed ID:
  21187793
• Pubmed Central ID:
  PMC3074942
• Document Type:
  Text
• Funding:
  ES00002/ES/NIEHS NIH HHS/United States ; ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; R01 ES009860-09/ES/NIEHS NIH HHS/United States ; T32 ES 07069/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11 pdf pages
• Volume:
  53
• Issue:
  1
• NIOSHTIC Number:
  nn:20038766
• Contact Point Address:
  Mary Berlik Rice, MD, Pulmonary and Critical Care Unit, Bulfinch, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114 USA
• Email:
  mrice2@partners.org
• Federal Fiscal Year:
  2011
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:20aa1c27538a7b992ecdc0c47a4c560ee6b84ae04a6264b99d8ae5a9c76582968996643c25bd8d79d1fb79a2c9b3ea45bdcdc88df56cc7f0cb153d550647c0d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/33193/cdc_33193_DS1.pdf
• File Type:
  [PDF - 332.78 KB ]