Targets for Combating the Evolution of Acquired Antibiotic
Resistance

Culyba, Matthew
J.; Mo, Charlie Y.; Kohli, Rahul M.

doi:10.1021/acs.biochem.5b00109

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Targets for Combating the Evolution of Acquired Antibiotic Resistance

Published Date:

Jun 05 2015

Publisher's site:

http://dx.doi.org/10.1021/acs.biochem.5b00109 New Site Icon

Source:

Biochemistry. 2015; 54(23):3573-3582.

[PDF-3.43 MB]

Details:

Personal Authors:

Culyba, Matthew J. ; Mo, Charlie Y. ; Kohli, Rahul M. ;

Keywords:

[+]

Pubmed ID:

26016604

Pubmed Central ID:

PMC4471857

Description:

Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance. This recognition underscores the importance of understanding how such genetic changes can arise. Here, we review recent advances in our understanding of the processes that contribute to the evolution of antibiotic resistance, with a particular focus on hypermutation mediated by the SOS pathway and horizontal gene transfer. We explore the molecular mechanisms involved in acquired resistance and discuss their viability as potential targets. We propose that additional studies into these adaptive mechanisms not only can provide insights into evolution but also can offer a strategy for potentiating our current antibiotic arsenal.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2-GM105444/DP/NCCDPHP CDC HHS/United States
T32 AR007442/AR/NIAMS NIH HHS/United States
T32 GM7229/GM/NIGMS NIH HHS/United States

Main Document Checksum:

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