Details:

Alternative Title:
Biochemistry
Publisher's site:
http://dx.doi.org/10.1021/acs.biochem.5b00109
Personal Author:
Culyba, Matthew J. ; Mo, Charlie Y. ; Kohli, Rahul M.
Culyba, Matthew J. ; Mo, Charlie Y. ; Kohli, Rahul M. Less -
Description:
Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance. This recognition underscores the importance of understanding how such genetic changes can arise. Here, we review recent advances in our understanding of the processes that contribute to the evolution of antibiotic resistance, with a particular focus on hypermutation mediated by the SOS pathway and horizontal gene transfer. We explore the molecular mechanisms involved in acquired resistance and discuss their viability as potential targets. We propose that additional studies into these adaptive mechanisms not only can provide insights into evolution but also can offer a strategy for potentiating our current antibiotic arsenal.
Subject:
[+]
Anti-Bacterial Agents
Current Topic
Drug Resistance, Bacterial
Evolution, Molecular
Gene Transfer, Horizontal
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Models, Genetic
Mutagenesis
SOS Response (Genetics)

Source:
Biochemistry. 2015; 54(23):3573-3582.
Pubmed ID:
26016604
Pubmed Central ID:
PMC4471857
Document Type:
Journal Article
Funding:
DP2-GM105444/DP/NCCDPHP CDC HHS/United States ; T32 AR007442/AR/NIAMS NIH HHS/United States ; T32 GM7229/GM/NIGMS NIH HHS/United States
DP2-GM105444/DP/NCCDPHP CDC HHS/United States ; T32 AR007442/AR/NIAMS NIH HHS/United States ; T32 GM7229/GM/NIGMS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b39d91a7def68f8b76d67625237f8fbab9243a9c00132a57394b9f1cb3acf57f
File Type:

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