Core–Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis

Details

• Alternative Title:
  ACS Nano
• Personal Author:
  Shah, Birju P. ; Pasquale, Nicholas ; De, Gejing ; Tan, Tao ; Ma, Jianjie ; Lee, Ki-Bum
• Description:
  Mitochondria-targeting peptides have garnered immense interest as potential chemotherapeutics in recent years. However, there is a clear need to develop strategies to overcome the critical limitations of peptides, such as poor solubility and the lack of target specificity, which impede their clinical applications. To this end, we report magnetic core-shell nanoparticle (MCNP)-mediated delivery of a mitochondria-targeting pro-apoptotic amphipathic tail-anchoring peptide (ATAP) to malignant brain and metastatic breast cancer cells. Conjugation of ATAP to the MCNPs significantly enhanced the chemotherapeutic efficacy of ATAP, while the presence of targeting ligands afforded selective delivery to cancer cells. Induction of MCNP-mediated hyperthermia further potentiated the efficacy of ATAP. In summary, a combination of MCNP-mediated ATAP delivery and subsequent hyperthermia resulted in an enhanced effect on mitochondrial dysfunction, thus resulting in increased cancer cell apoptosis.
• Subjects:
  Amphipathic Tail-anchoring Peptide Article Combined Therapy Magnetically Facilitated Delivery Magnetic Core−shell Nanoparticle Magnetic Hyperthermia Mitochondria-targeting Peptide
• Source:
  ACS Nano. 2014; 8(9):9379-9387.
• Pubmed ID:
  25133971
• Pubmed Central ID:
  PMC4174096
• Document Type:
  Journal Article
• Funding:
  1DP20D006462-01/DP/NCCDPHP CDC HHS/United States ; 1R21NS085569-01/NS/NINDS NIH HHS/United States
• Volume:
  8
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eb92a846c8e0b54776bd2af761b36851b950d46309cd3c1a1bbca085020e7214
• Download URL:
  https://stacks.cdc.gov/view/cdc/32988/cdc_32988_DS1.pdf
• File Type:
  [PDF - 3.31 MB ]