Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study

Details

• Alternative Title:
  J Autism Dev Disord
• Personal Author:
  Durkin, Maureen S. ; Allerton, Lindsay ; Maenner, Matthew J.
• Description:
  Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (<12) and long (>84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24-47 months (p < 0.05). The long IPI association was partially confounded by history of previous pregnancy loss.
• Subjects:
  Article Autism Autism Spectrum Disorder Birth Intervals Child Epidemiology Female Humans Male Pregnancy Pregnancy Intervals Risk Factors Siblings Wisconsin

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• Source:
  J Autism Dev Disord. 45(7):2056-2066.
• Pubmed ID:
  25636677
• Pubmed Central ID:
  PMC4474747
• Document Type:
  Journal Article
• Funding:
  P30 HD003352/HD/NICHD NIH HHS/United States ; P30HD03352/HD/NICHD NIH HHS/United States ; UR3/CCU523235/PHS HHS/United States ; UR3/DD000078/DD/NCBDD CDC HHS/United States ; UR3/DD000677/DD/NCBDD CDC HHS/United States
• Volume:
  45
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6e3db68fbd22446e149b6df7987c6f247c273db6b3eac107b51feaa29ccfa581
• Download URL:
  https://stacks.cdc.gov/view/cdc/32929/cdc_32929_DS1.pdf
• File Type:
  [PDF - 365.36 KB ]