Details:

Alternative Title:
Environ Res
Publisher's site:
http://dx.doi.org/10.1016/j.envres.2013.12.004
Personal Author:
Mortensen, Mary E. ; Calafat, Antonia M. ; Ye, Xiaoyun ; Wong, Lee-Yang ; Wright, David J. ; ... More +
Mortensen, Mary E. ; Calafat, Antonia M. ; Ye, Xiaoyun ; Wong, Lee-Yang ; Wright, David J. ; Pirkle, James L. ; Merrill, Lori S. ; Moye, John ; Less -
Description:
Environmental phenols are a group of chemicals with widespread uses in consumer and personal care products, food and beverage processing, and in pesticides. We assessed exposure to benzophenone-3, bisphenol A (BPA), triclosan, methyl- and propyl parabens, and 2,4- and 2,5-dichlorophenol or their precursors in 506 pregnant women enrolled in the National Children's Study (NCS) Vanguard Study. We measured the urinary concentrations of the target phenols by using online solid-phase extraction-isotope dilution high performance liquid chromatography-tandem mass spectrometry. NCS women results were compared to those of 524 similar-aged women in the National Health and Nutrition Examination Survey (NHANES) 2009-2010, and to 174 pregnant women in NHANES 2005-2010. In the NCS women, we found significant racial/ethnic differences (p<0.05) in regression adjusted mean concentrations of benzophenone-3, triclosan, 2,4- and 2,5-dichlorophenol, but not of BPA. Urinary 2,4- and 2,5-dichlorophenol concentrations were highly correlated (r=0.66, p<0.0001). Except for BPA and triclosan, adjusted mean concentrations were significantly different across the 7 study sites. Education was marginally significant for benzophenone-3, triclosan, propyl paraben, and 2,5-dichlorophenol. Urinary concentrations of target phenols in NCS pregnant women and U.S. women and pregnant women were similar. In NCS pregnant women, race/ethnicity and geographic location determined urinary concentrations of most phenols (except BPA), suggesting differential exposures. NCS Main Study protocols should collect urine biospecimens and information about exposures to environmental phenols.
Subject:
[+]
Adolescent
Adult
Child
Child Development
Chromatography, High Pressure Liquid
Environmental Exposure
Environmental Monitoring
Environmental Pollutants
Female
Financing, Government
Humans
Middle Aged
Phenols
Pilot Projects
Pregnancy
Prenatal Exposure Delayed Effects
Solid Phase Extraction
Tandem Mass Spectrometry
Young Adult

Source:
Environ Res. 129:32-38. ;
Pubmed ID:
24529000
Pubmed Central ID:
PMC4530794
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Name as Subject:
National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.) ;
National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.) ; Less -
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:590763968412145e9a66a274c79114da1e73c09ff7685ebbbfd7431e880226c4
File Type:

Supporting Files

• 	NIHMS712123-supplement-Supp_Table.docx	docx
  	NIHMS712123-supplement-Supp_Urine_Collection.pdf	pdf
  	nihms712123.nxml	bin

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