Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2108.150084
Personal Author:
Pollett, Simon ; Nelson, Martha I. ; Kasper, Matthew ; Tinoco, Yeny ; Simons, Mark ; ... More +
Pollett, Simon ; Nelson, Martha I. ; Kasper, Matthew ; Tinoco, Yeny ; Simons, Mark ; Romero, Candice ; Silva, Marita ; Lin, Xudong ; Halpin, Rebecca A. ; Fedorova, Nadia ; Stockwell, Timothy B. ; Wentworth, David ; Holmes, Edward C. ; Bausch, Daniel G. Less -
Description:
It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source-sink model for a Latin American country. Viruses were obtained during 2010-2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains.
Subject:
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Evolution
Gene Pool
H3N2
Human Influenza
Influenza
Influenza A(H3N2) Virus
Influenza Virus
Interseasonal Extinction
Peru
Phylogeny
Phylogeography
Phylogeography Of Influenza A(H3N2) Virus In Peru, 2010–2012
Research
Source Population
Source–sink Dynamic
Source–sink Model
Subtropical
Surveillance
Tropical
Viral Traffic
Viruses

Source:
Emerg Infect Dis. 21(8):1330-1338.
Pubmed ID:
26196599
Pubmed Central ID:
PMC4517729
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:79a91b33e84aafd164ca35f473c7ab2145c9dd778f88b88c1c8e6dbc13db2103
File Type:

Supporting Files

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  	15-0084-Techapp-s1.pdf	pdf
  	15-0084.nxml	txt

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