Occupational exposure to extremely low frequency magnetic fields and brain tumour risks in the INTEROCC study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Turner, Michelle C ; Benke, Geza ; Bowman, Joseph D ; Figuerola, Jordi ; Fleming, Sarah ; Hours, Martine ; Kincl, Laurel ; Krewski, Daniel ; McLean, Dave ; Parent, Marie-Elise ; Richardson, Lesley ; Sadetzki, Siegal ; Schlaefer, Klaus ; Schlehofer, Brigitte ; Schüz, Joachim ; Siemiatycki, Jack ; van Tongeren, Martie ; Cardis, Elisabeth
• Description:
  Background
  
  Occupational exposure to extremely low frequency magnetic fields (ELF) is a suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure may be associated with specific histologic types of brain tumours. This study examines the association between ELF and brain tumours in the large-scale INTEROCC study.
  
  Methods
  
  Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix assigned. Estimates of cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime, and 1–4, 5–9, and 10+ years prior to the diagnosis/reference date.
  
  Results
  
  There were 3,761 included brain tumour cases (1,939 glioma, 1,822 meningioma) and 5,404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1–4 years prior to the diagnosis/reference date and glioma (odds ratio (OR) ≥ 90th percentile vs < 25th percentile = 1.67, 95% confidence interval (CI) 1.36–2.07, p < 0.0001 linear trend), and, somewhat weaker associations with meningioma (OR ≥ 90th percentile vs < 25th percentile = 1.23, 95% CI 0.97–1.57, p = 0.02 linear trend).
  
  Conclusions
  
  Results showed positive associations between ELF in the recent past and glioma.
  
  Impact
  
  Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumourigenesis.
  
  
• Subjects:
  Adult Aged Brain Neoplasms Female Humans Magnetic Fields Male Middle Aged Occupational Diseases Occupational Exposure Risk Factors

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 23(9):1863-1872.
• Pubmed ID:
  24935666
• Pubmed Central ID:
  PMC4154968
• Document Type:
  Journal Article
• Funding:
  1R01CA124759/CA/NCI NIH HHS/United States ; DAL2/Intramural CDC HHS/United States ; MOP-42525/Canadian Institutes of Health Research/Canada ; R01 CA124759/CA/NCI NIH HHS/United States ; Department of Health/United Kingdom
• Place as Subject:
  Australia ; Canada ; France ; Germany ; Great Britain
• Volume:
  23
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dcd92c3ab04cc7f3f25b26ccf1972e91d7c8dcb73cfd8eb25a79bc5116379329
• Download URL:
  https://stacks.cdc.gov/view/cdc/32537/cdc_32537_DS1.pdf
• File Type:
  [PDF - 217.00 KB ]