Details:

Alternative Title:
Influenza Other Respir Viruses
Publisher's site:
http://dx.doi.org/10.1111/irv.12302
Personal Author:
Kittikraisak, Wanitchaya ; Suntarattiwong, Piyarat ; Levy, Jens ; Fernandez, Stefan ; Dawood, Fatimah S. ; ... More +
Kittikraisak, Wanitchaya ; Suntarattiwong, Piyarat ; Levy, Jens ; Fernandez, Stefan ; Dawood, Fatimah S. ; Olsen, Sonja J. ; Chotpitayasunondh, Tawee Less -
Description:
Background

Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group.

Methods

During August 2011–May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription–polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio).

Results

During 2011–2013, 968 children were enrolled (median age, 10·3 months); 948 (97·9%) had a vaccination record and were included. Of these, 394 (41·6%) had ≥1 medical conditions. Vaccination coverage for the 2011–2012 and 2012–2013 seasons was 29·3% (93/317) and 30·0% (197/656), respectively. In 2011–2012, there were 213 ARI episodes, of which 10 (4·6%) were influenza positive (2·3 per 1000 vaccinated and 3·8 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], −72, 88). In 2012–2013, there were 846 ARIs, of which 52 (6·2%) were influenza positive (1·8 per 1000 vaccinated and 4·5 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%).

Conclusion

Influenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand.


Subjects:
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Child, Preschool Children Cohort Studies Coverage Effectiveness Female Humans Immunization Programs Infant Infant, Newborn Influenza Influenza, Human Influenza Vaccines Male Original Articles Prospective Studies Real-Time Polymerase Chain Reaction Seasons Vaccination
Source:
Influenza Other Respir Viruses. 2015; 9(2):85-93.
Pubmed ID:
25557920
Pubmed Central ID:
PMC4353321
Document Type:
Journal Article
Funding:
5U01GH000152/GH/CGH CDC HHS/United States
Place as Subject:
Thailand
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4e3bb2dc04869a285fc98e4cc50a1353f2dce8a0a9a6055592fd95532758959b
Download URL:
https://stacks.cdc.gov/view/cdc/32366/cdc_32366_DS1.pdf
File Type:

Supporting Files

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  	irv0009-0085-f1.jpg	jpeg
  	irv0009-0085-sd1.doc	doc
  	irv0009-0085.nxml	txt
  	license.txt	txt

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