Influenza vaccination coverage and effectiveness in young children in Thailand, 2011–2013

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Kittikraisak, Wanitchaya ; Suntarattiwong, Piyarat ; Levy, Jens ; Fernandez, Stefan ; Dawood, Fatimah S. ; Olsen, Sonja J. ; Chotpitayasunondh, Tawee
• Description:
  Background
  
  Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group.
  
  Methods
  
  During August 2011–May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-year prospective cohort study. Parents were contacted weekly about acute respiratory illness (ARI) in their child. Ill children had combined nasal and throat swabs tested for influenza viruses by real-time reverse transcription–polymerase chain reaction. Influenza vaccination status was verified with vaccination cards. The Cox proportional hazards approach was used to estimate hazard ratios. Vaccine effectiveness (VE) was estimated as 100% x (1-hazard ratio).
  
  Results
  
  During 2011–2013, 968 children were enrolled (median age, 10·3 months); 948 (97·9%) had a vaccination record and were included. Of these, 394 (41·6%) had ≥1 medical conditions. Vaccination coverage for the 2011–2012 and 2012–2013 seasons was 29·3% (93/317) and 30·0% (197/656), respectively. In 2011–2012, there were 213 ARI episodes, of which 10 (4·6%) were influenza positive (2·3 per 1000 vaccinated and 3·8 per 1000 unvaccinated child-weeks). The VE was 55% (95% confidence interval [CI], −72, 88). In 2012–2013, there were 846 ARIs, of which 52 (6·2%) were influenza positive (1·8 per 1000 vaccinated and 4·5 per 1000 unvaccinated child-weeks). The VE was 64% (CI, 13%, 85%).
  
  Conclusion
  
  Influenza vaccination coverage among young children in Thailand was low, although vaccination was moderately effective. Continued efforts are needed to increase influenza vaccination coverage and evaluate VE among young children in Thailand.
  
  
• Subjects:
  Child, Preschool Children Cohort Studies Coverage Effectiveness Female Humans Immunization Programs Infant Infant, Newborn Influenza Influenza, Human Influenza Vaccines Male Original Articles Prospective Studies Real-Time Polymerase Chain Reaction Seasons Vaccination

  More +
• Source:
  Influenza Other Respir Viruses. 2015; 9(2):85-93.
• Pubmed ID:
  25557920
• Pubmed Central ID:
  PMC4353321
• Document Type:
  Journal Article
• Funding:
  5U01GH000152/GH/CGH CDC HHS/United States
• Place as Subject:
  Thailand
• Volume:
  9
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4e3bb2dc04869a285fc98e4cc50a1353f2dce8a0a9a6055592fd95532758959b
• Download URL:
  https://stacks.cdc.gov/view/cdc/32366/cdc_32366_DS1.pdf
• File Type:
  [PDF - 159.71 KB ]