The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers

Details

• Alternative Title:
  BMC Public Health
• Personal Author:
  Ramin, Cody A ; Massa, Jennifer ; Wegrzyn, Lani R ; Brown, Susan B ; Pierre-Paul, Jeffrey ; Devore, Elizabeth E ; Hankinson, Susan E ; Schernhammer, Eva S
• Description:
  Background
  
  Adult body mass index (BMI) has been associated with urinary melatonin levels in humans; however, whether earlier-life body size is associated with melatonin, particularly among night shift workers, remains unknown.
  
  Methods
  
  We evaluated associations of birth weight, body shape (or somatotype) at ages 5 and 10, BMI at age 18 and adulthood, weight change since age 18, waist circumference, waist to hip ratio, and height with creatinine-adjusted morning urinary melatonin (6-sulfatoxymelatonin, aMT6s) levels among 1,343 healthy women (aged 32–53 at urine collection, 1996–1999) in the Nurses’ Health Study (NHS) II cohort. Using multivariable linear regression, we computed least-square mean aMT6s levels across categories of body size, and evaluated whether these associations were modified by night shift work.
  
  Results
  
  Adult BMI was inversely associated with aMT6s levels (mean aMT6s levels = 34 vs. 50 ng/mg creatinine, comparing adult BMI ≥30 vs. <20 kg/m2; Ptrend <0.0001); however, other measures of body size were not related to aMT6s levels after accounting for adult BMI. Night shifts worked prior to urine collection, whether recent or cumulatively over time, did not modify the association between adult BMI and aMT6s levels (e.g., Pinteraction = 0.72 for night shifts worked within two weeks of urine collection).
  
  Conclusions
  
  Our results suggest that adult BMI, but not earlier measures of body size, is associated with urinary aMT6s levels in adulthood. These observations did not vary by night shift work status, and suggest that adult BMI may be an important mechanism by which melatonin levels are altered and subsequently influence chronic disease risk.
  
  
• Subjects:
  Adult Body Mass Index Body Size Circadian Rhythm Cohort Studies Creatinine Female Health Personnel Humans Melatonin Middle Aged Waist-Hip Ratio Workload Work Schedule Tolerance Young Adult

  More +
• Source:
  BMC Public Health. 15.
• Pubmed ID:
  25943349
• Pubmed Central ID:
  PMC4424517
• Document Type:
  Journal Article
• Funding:
  R01 CA67262/CA/NCI NIH HHS/United States ; R01 OH009803/OH/NIOSH CDC HHS/United States ; R25 CA098566/CA/NCI NIH HHS/United States ; UM1 CA176726/CA/NCI NIH HHS/United States
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e82116ee820c48e49d004e4b9d645275d73313a2f29f7b1947a29c8f47d61a2e
• Download URL:
  https://stacks.cdc.gov/view/cdc/32353/cdc_32353_DS1.pdf
• File Type:
  [PDF - 329.27 KB ]