Tuberculosis active case finding: uptake and diagnostic yield among minibus drivers in urban South Africa

Details

• Alternative Title:
  BMC Public Health
• Personal Author:
  Mabuto, Tonderai ; Zwane, Ephraim ; Chihota, Violet ; Gresak, Gillian ; Charalambous, Salome ; Churchyard, Gavin J ; Hoffmann, Christopher J
• Description:
  Background
  
  Tuberculosis (TB) active case finding is a part of TB control in areas of higher TB prevalence. Congested public transportation settings may be areas of increased TB transmission. We evaluated the uptake and diagnostic yield of an active TB screening program among minibus drivers in a large public transportation facility in Johannesburg, South Africa.
  
  Methods
  
  Over an eight month period, we intensively recruited minibus drivers for TB screening with a goal of 80% uptake among the estimated 2000 drivers. All participants were screened for TB symptoms, offered HIV testing, and had sputum collected for smear microscopy and liquid culture.
  
  Results
  
  686 drivers were screened for TB, representing an uptake of only 34% of all drivers (43% of the target screening). Ten drivers (1.5%) were culture positive for TB, nine of whom were sputum smear microscopy negative. Factors associated with previously undiagnosed TB included a history of incarceration (odds ratio [OR] 5.5, 95% confidence interval: 1.1, 27.3) and HIV positivity (OR 5.3, 95% confidence interval: 1.1, 26.3).
  
  Conclusions
  
  We identified undiagnosed pulmonary TB cases among drivers but at a level that may be insufficient to justify systematic case finding in this population considering the poor uptake.
  
  
• Subjects:
  Active Case Finding Adult Automobile Driving Cross-sectional Female HIV HIV Infections Humans Male Mass Screening Microscopy Middle Aged Operational Research Prevalence Research Article Sputum Transmission Transport Transportation Tuberculosis Tuberculosis, Pulmonary Urban Population

  More +
• Source:
  BMC Public Health. 15.
• DOI:
  http://dx.doi.org/10.1186/s12889-015-1592-x
• Pubmed ID:
  25880544
• Pubmed Central ID:
  PMC4364653
• Document Type:
  Journal Article
• Funding:
  U2R TW007370/TW/FIC NIH HHS/United States ; U62 PS024055/PS/NCHHSTP CDC HHS/United States ; K23 AI083099/AI/NIAID NIH HHS/United States ; AI083099/AI/NIAID NIH HHS/United States ; PS024055/PS/NCHHSTP CDC HHS/United States ; U2G PS000811/PS/NCHHSTP CDC HHS/United States ; GPS000811/PEPFAR/United States
• Name as Subject:
  United States. President's Emergency Plan For AIDS Relief (PEPFAR)
• Place as Subject:
  South Africa
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:d8d5df6861fc982c0d310da6c8d0c77be99e00d8f7ce978b3044b3ac1c1cccf38470c39ba2a53265b52e0e43638b57279a06a3dabdbbeb4623a74ecdb8b981b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/32350/cdc_32350_DS1.pdf
• File Type:
  [PDF - 337.98 KB ]