Welcome to CDC stacks |
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
Filetype[PDF-1.56 MB]


Details:
No Related Documents.
You May Also Like:
  1. Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials
    Personal Author:
    Minella, AL; Mowat, FM; Willett, KL; Sledge, D; Bartoe, JT; Bennett, J; Petersen-Jones, SM;
    Published Date:
    Jul 24 2014
    Source:
    Gene Ther. 2014; 21(10):913-920.
    Description:
    The cat is emerging as a promising large animal model for preclinical testing of retinal dystrophy therapies, for example, by gene therapy. However, there is a paucity of studies investigating viral vector gene transfer to the feline retina. We there...
    File Type:
    Filetype[PDF - 2.09 MB]
  2. Optical Control of Mammalian Endogenous Transcription and Epigenetic States
    Personal Author:
    Konermann, Silvana; Brigham, Mark D.; Trevino, Alexandro; Hsu, Patrick D.; Heidenreich, Matthias; Cong, Le; Platt, Randall J.; Scott, David A.; Church, George M.; Zhang, Feng;
    Published Date:
    Aug 23 2013
    Source:
    Nature. 500(7463):472-476.
    Description:
    The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates approaches that enable spa...
    File Type:
    Filetype[PDF - 1.06 MB]
  3. In silico reconstruction of the viral evolutionary lineage yields a potent gene therapy vector
    Personal Author:
    Zinn, Eric; Pacouret, Simon; Khaychuk, Vadim; Turunen, Heikki T.; Carvalho, Livia S.; Andres-Mateos, Eva; Shah, Samiksha; Shelke, Rajani; Maurer, Anna C.; Plovie, Eva; Xiao, Ru; Vandenberghe, Luk H.;
    Published Date:
    Jul 30 2015
    Source:
    Cell Rep. 12(6):1056-1068.
    Description:
    Adeno-associated virus (AAV) vectors have emerged as a gene-delivery platform with demonstrated safety and efficacy in a handful of clinical trials for monogenic disorders. However, limitations of the current generation vectors often prevent broader ...
    File Type:
    Filetype[PDF - 2.53 MB]
  4. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
    Personal Author:
    Deverman, Benjamin E.; Pravdo, Piers L.; Simpson, Bryan P.; Kumar, Sripriya Ravindra; Chan, Ken Y.; Banerjee, Abhik; Wu, Wei-Li; Yang, Bin; Huber, Nina; Pasca, Sergiu P.; Gradinaru, Viviana;
    Published Date:
    Feb 1 2016
    Source:
    Nat Biotechnol. 34(2):204-209.
    Description:
    Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer. However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics. Here we ...
    File Type:
    Filetype[PDF - 2.06 MB]
  5. Noninvasive optical inhibition with a red-shifted microbial rhodopsin
    Personal Author:
    Chuong, Amy S; Miri, Mitra L; Busskamp, Volker; Matthews, Gillian A C; Acker, Leah C; Sørensen, Andreas T; Young, Andrew; Klapoetke, Nathan C; Henninger, Mike A; Kodandaramaiah, Suhasa B; Ogawa, Masaaki; Ramanlal, Shreshtha B; Bandler, Rachel C; Allen, Brian D; Forest, Craig R; Chow, Brian Y; Han, Xue; Lin, Yingxi; Tye, Kay M; Roska, Botond; Cardin, Jessica A; Boyden, Edward S;
    Published Date:
    Jul 06 2014
    Source:
    Nat Neurosci. 17(8):1123-1129.
    Description:
    Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin, ...
    File Type:
    Filetype[PDF - 1.73 MB]