Longitudinal Associations between Sex, Diabetes Self-Care, and Health-Related Quality of Life Among Youth with Type 1 or Type 2 Diabetes Mellitus

Naughton, Michelle J.; Yi-Frazier, Joyce P.; Morgan, Timothy M.; Seid, Michael; Lawrence, Jean M.; Klingensmith, Georgeanna J.; Waitzfelder, Beth; Standiford, Debra A.; Loots, Beth

doi:10.1016/j.jpeds.2014.01.027

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Longitudinal Associations between Sex, Diabetes Self-Care, and Health-Related Quality of Life Among Youth with Type 1 or Type 2 Diabetes Mellitus

6 2014
By Naughton, Michelle J. ; Yi-Frazier, Joyce P. ; Morgan, Timothy M. ; ...
http://dx.doi.org/10.1016/j.jpeds.2014.01.027
Source: J Pediatr. 2014; 164(6):1376-83.e1

[PDF-327.06 KB]

English

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Details:

Alternative Title:

J Pediatr
Personal Author:

Naughton, Michelle J. ; Yi-Frazier, Joyce P. ; Morgan, Timothy M. ; Seid, Michael ; Lawrence, Jean M. ; ... More +

Naughton, Michelle J. ; Yi-Frazier, Joyce P. ; Morgan, Timothy M. ; Seid, Michael ; Lawrence, Jean M. ; Klingensmith, Georgeanna J. ; Waitzfelder, Beth ; Standiford, Debra A. ; Loots, Beth Less -
Description:

Objective

To examine the longitudinal associations between sex, diabetes self-care and the health-related quality of life (HRQL) of children and adolescents with Type 1 or Type 2 diabetes.

Study design

The sample included 910 Type 1 and 241 Type 2 participants, ages 10–22 at baseline, from SEARCH for Diabetes in Youth, a longitudinal observational study. The primary outcome measure was the Pediatric Quality of Life Inventory (PedsQL). Repeated measures, mixed model regression analysis was conducted using data from baseline and at least one follow-up assessment, spanning approximately 4 years.

Results

HRQL was higher among those with Type 1 versus Type 2 diabetes. Among Type 1 participants, higher (better) PedsQL total scores over time were related to higher parent education (p=0.0007), lower HbA1c values (p<.0001), and greater physical activity during the past 7 days (p=0.0001). There was a significant interaction between sex and age (p<0.0001); girls’ HRQL remained stable or decreased over time, whereas males’ HRQL increased. For participants with Type 2 diabetes, there was no significant interaction by age and sex, but lower total HRQL was related to being female (p=0.011) and higher BMI-z scores (p=0.014).

Conclusions

HRQL in this cohort varied by diabetes type. The interaction between sex and age for Type 1 participants, coupled with poorer HRQL among females than males with Type 2 diabetes, suggests the impacts of diabetes on HRQL differ by sex and should be considered in clinical management. Encouraging physical activity and weight control continue to be important in improving HRQL.
Subjects:

[+]

Adolescent Age Factors Article Attitude To Health Blood Sugar Testing Body Mass Index Child Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Exercise Female Health Knowledge, Attitudes, Practice Humans Hypoglycemic Agents Life Style Longitudinal Studies Male Patient Compliance PedsQL Quality Of Life SEARCH For Diabetes In Youth Self Care Severity Of Illness Index Sex Factors Young Adult
Source:

J Pediatr. 2014; 164(6):1376-83.e1
Pubmed ID:

24582483
Pubmed Central ID:

PMC4500167
Document Type:

Journal Article
Funding:

P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU419249/PHS HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU919219/PHS HHSUnited States/ ; ... More +

P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU419249/PHS HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU919219/PHS HHSUnited States/ ; P30 DK57516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU519239/PHS HHSUnited States/ ; U18DP002710-01/DP/NCCDPHP CDC HHSUnited States/ ; U58/CCU019235-4/PHS HHSUnited States/ ; UL1 TR001082/TR/NCATS NIH HHSUnited States/ ; K23 DK089017/DK/NIDDK NIH HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; 1U18DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU819241-3/PHS HHSUnited States/ ; M01RR00037/RR/NCRR NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP003256/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000245/DP/NCCDPHP CDC HHSUnited States/ ; DP-05-069/DP/NCCDPHP CDC HHSUnited States/ ; U18DP002708-01/DP/NCCDPHP CDC HHSUnited States/ ; 200-2010-35171/PHS HHSUnited States/ ; DP-10-001/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U58CCU919256/PHS HHSUnited States/ ; 00097/PHS HHSUnited States/ ; 1UL1RR026314-01/RR/NCRR NIH HHSUnited States/ ; U18DP000247-06A1/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR029882/RR/NCRR NIH HHSUnited States/ ; M01 RR00069/RR/NCRR NIH HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR026314/RR/NCRR NIH HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; UL1RR029882/RR/NCRR NIH HHSUnited States/ Less -
Volume:

164
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:9325380bb17a23589fbb3fe66bdf8b24eab6cecda30f1599eb96588acd43209b
Download URL:

https://stacks.cdc.gov/view/cdc/32055/cdc_32055_DS1.pdf
File Type:

nihms571601.nxml

xml

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