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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study
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Details:
  • Pubmed ID:
    25280447
  • Pubmed Central ID:
    PMC4495040
  • Description:
    In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

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  • Funding:
    2R01NR04749/NR/NINR NIH HHS/United States
    AI069419/AI/NIAID NIH HHS/United States
    AI38858/AI/NIAID NIH HHS/United States
    CC02-SD-003/CC/ODCDC CDC HHS/United States
    CC99-SD003/CC/ODCDC CDC HHS/United States
    K02 DA017277/DA/NIDA NIH HHS/United States
    K02DA017277/DA/NIDA NIH HHS/United States
    K08 MH001584/MH/NIMH NIH HHS/United States
    K08 MH01584/MH/NIMH NIH HHS/United States
    K23 MH001862/MH/NIMH NIH HHS/United States
    K23MH01862/MH/NIMH NIH HHS/United States
    K24 MH093243/MH/NIMH NIH HHS/United States
    K24MH093243/MH/NIMH NIH HHS/United States
    P01 MH049548/MH/NIMH NIH HHS/United States
    P01MH49548/MH/NIMH NIH HHS/United States
    P30 AI027757/AI/NIAID NIH HHS/United States
    P30 AI050410/AI/NIAID NIH HHS/United States
    P30 MH043520/MH/NIMH NIH HHS/United States
    P30AI050410/AI/NIAID NIH HHS/United States
    P30AI27757/AI/NIAID NIH HHS/United States
    R01 DA011869/DA/NIDA NIH HHS/United States
    R01 DA013826/DA/NIDA NIH HHS/United States
    R01 DA015215/DA/NIDA NIH HHS/United States
    R01 DA015679/DA/NIDA NIH HHS/United States
    R01 MH054907/MH/NIMH NIH HHS/United States
    R01 MH058986/MH/NIMH NIH HHS/United States
    R01 MH061173/MH/NIMH NIH HHS/United States
    R01 MH061695/MH/NIMH NIH HHS/United States
    R01 MH068197/MH/NIMH NIH HHS/United States
    R01 MH078773/MH/NIMH NIH HHS/United States
    R01 NR004749/NR/NINR NIH HHS/United States
    R01AI41413/AI/NIAID NIH HHS/United States
    R01DA015679/DA/NIDA NIH HHS/United States
    R01DA11869/DA/NIDA NIH HHS/United States
    R01DA13826/DA/NIDA NIH HHS/United States
    R01DA15215/DA/NIDA NIH HHS/United States
    R01MH068197/MH/NIMH NIH HHS/United States
    R01MH078773/MH/NIMH NIH HHS/United States
    R01MH54907/MH/NIMH NIH HHS/United States
    R01MH58986/MH/NIMH NIH HHS/United States
    R01MH61173/MH/NIMH NIH HHS/United States
    R01MH61695/MH/NIMH NIH HHS/United States
    R01NR04749/NR/NINR NIH HHS/United States
    U01 AI038858/AI/NIAID NIH HHS/United States
    U01 AI069419/AI/NIAID NIH HHS/United States
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