The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Details

• Alternative Title:
  AIDS Behav
• Personal Author:
  Simoni, Jane M. ; Huh, David ; Wang, Yan ; Wilson, Ira B. ; Reynolds, Nancy R. ; Remien, Robert H. ; Goggin, Kathy ; Gross, Robert ; Rosen, Marc I. ; Schneiderman, Neil ; Arnsten, Julia ; Golin, Carol E. ; Erlen, Judith A. ; Bangsberg, David R. ; Liu, Honghu
• Description:
  In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
• Subjects:
  Adult Aged Anti-HIV Agents Female Health Promotion HIV-1 HIV Infections Humans Male Medication Adherence Middle Aged Program Evaluation Reproducibility Of Results Self Report Viral Load

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• Source:
  AIDS Behav. 2014; 18(12):2285-2290.
• Pubmed ID:
  25280447
• Pubmed Central ID:
  PMC4495040
• Document Type:
  Journal Article
• Funding:
  2R01NR04749/NR/NINR NIH HHS/United States ; AI069419/AI/NIAID NIH HHS/United States ; AI38858/AI/NIAID NIH HHS/United States ; CC02-SD-003/CC/ODCDC CDC HHS/United States ; CC99-SD003/CC/ODCDC CDC HHS/United States ; K02 DA017277/DA/NIDA NIH HHS/United States ; K02DA017277/DA/NIDA NIH HHS/United States ; K08 MH001584/MH/NIMH NIH HHS/United States ; K08 MH01584/MH/NIMH NIH HHS/United States ; K23 MH001862/MH/NIMH NIH HHS/United States ; K23MH01862/MH/NIMH NIH HHS/United States ; K24 MH093243/MH/NIMH NIH HHS/United States ; K24MH093243/MH/NIMH NIH HHS/United States ; P01 MH049548/MH/NIMH NIH HHS/United States ; P01MH49548/MH/NIMH NIH HHS/United States ; P30 AI027757/AI/NIAID NIH HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; P30 MH043520/MH/NIMH NIH HHS/United States ; P30AI050410/AI/NIAID NIH HHS/United States ; P30AI27757/AI/NIAID NIH HHS/United States ; R01 DA011869/DA/NIDA NIH HHS/United States ; R01 DA013826/DA/NIDA NIH HHS/United States ; R01 DA015215/DA/NIDA NIH HHS/United States ; R01 DA015679/DA/NIDA NIH HHS/United States ; R01 MH054907/MH/NIMH NIH HHS/United States ; R01 MH058986/MH/NIMH NIH HHS/United States ; R01 MH061173/MH/NIMH NIH HHS/United States ; R01 MH061695/MH/NIMH NIH HHS/United States ; R01 MH068197/MH/NIMH NIH HHS/United States ; R01 MH078773/MH/NIMH NIH HHS/United States ; R01 NR004749/NR/NINR NIH HHS/United States ; R01AI41413/AI/NIAID NIH HHS/United States ; R01DA015679/DA/NIDA NIH HHS/United States ; R01DA11869/DA/NIDA NIH HHS/United States ; R01DA13826/DA/NIDA NIH HHS/United States ; R01DA15215/DA/NIDA NIH HHS/United States ; R01MH068197/MH/NIMH NIH HHS/United States ; R01MH078773/MH/NIMH NIH HHS/United States ; R01MH54907/MH/NIMH NIH HHS/United States ; R01MH58986/MH/NIMH NIH HHS/United States ; R01MH61173/MH/NIMH NIH HHS/United States ; R01MH61695/MH/NIMH NIH HHS/United States ; R01NR04749/NR/NINR NIH HHS/United States ; U01 AI038858/AI/NIAID NIH HHS/United States ; U01 AI069419/AI/NIAID NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  18
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9a15986fb986ee5769ea8095c69f3bb2f35211d071d2d68c3138607696c7e278
• Download URL:
  https://stacks.cdc.gov/view/cdc/32039/cdc_32039_DS1.pdf
• File Type:
  [PDF - 119.53 KB ]