The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Simoni, Jane M.; Huh, David; Wang, Yan; Wilson, Ira B.; Reynolds, Nancy R.; Remien, Robert H.; Goggin, Kathy; Gross, Robert; Rosen, Marc I.; Schneiderman, Neil; Arnsten, Julia; Golin, Carol E.; Erlen, Judith A.; Bangsberg, David R.; Liu, Honghu

doi:10.1007/s10461-014-0905-x

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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Published Date:

Dec 2014

Publisher's site:

http://dx.doi.org/10.1007/s10461-014-0905-x

Source:

AIDS Behav. 2014; 18(12):2285-2290.

Language:

English

[PDF-119.53 KB]

Details:

Alternative Title:

AIDS Behav

Personal Author:

Simoni, Jane M. ; Huh, David ; Wang, Yan ; Wilson, Ira B. ; Reynolds, Nancy R. ; ... More ▼

Description:

In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

Subject:

[+]

Pubmed ID:

25280447

Pubmed Central ID:

PMC4495040

Document Type:

Journal Article

Funding:

2R01NR04749/NR/NINR NIH HHS/United States ; AI069419/AI/NIAID NIH HHS/United States ; AI38858/AI/NIAID NIH HHS/United States ; CC02-SD-003/CC/ODCDC CDC HHS/United States ; CC99-SD003/CC/ODCDC CDC HHS/United States ; ... More ▼

Place as Subject:

United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

nihms633203.nxml

application/octet-stream

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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

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