Brains, Genes and Primates

Details

• Alternative Title:
  Neuron
• Personal Author:
  Belmonte, Juan Carlos Izpisua ; Callaway, Edward M. ; Churchland, Patricia ; Caddick, Sarah J. ; Feng, Guoping ; Homanics, Gregg E. ; Lee, Kuo-Fen ; Leopold, David A. ; Miller, Cory T. ; Mitchell, Jude F. ; Mitalipov, Shoukhrat ; Moutri, Alysson R. ; Movshon, J. Anthony ; Okano, Hideyuki ; Reynolds, John H. ; Ringach, Dario ; Sejnowski, Terrence J. ; Silva, Afonso C. ; Strick, Peter L. ; Wu, Jun ; Zhang, Feng
• Description:
  One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward.
• Subjects:
  Animals Biological Evolution Brain Genes Humans Mice Models, Biological Primates
• Source:
  Neuron. 2015; 86(3):617-631
• Pubmed ID:
  25950631
• Pubmed Central ID:
  PMC4425847
• Document Type:
  Journal Article
• Funding:
  1-DP2-OD006495-01/OD/NIH HHSUnited States/ ; P30 NS076405/NS/NINDS NIH HHSUnited States/ ; P51 OD011092/OD/NIH HHSUnited States/ ; R21 MH104756/MH/NIMH NIH HHSUnited States/ ; DP2 OD006495/OD/NIH HHSUnited States/ ; P40 OD010996/OD/NIH HHSUnited States/ ; R01-HD057121/HD/NICHD NIH HHSUnited States/ ; R01 MH110049/MH/NIMH NIH HHSUnited States/ ; 5DP1-MH100706/DP/NCCDPHP CDC HHSUnited States/ ; R01 NS024328/NS/NINDS NIH HHSUnited States/ ; R01 EY021214/EY/NEI NIH HHSUnited States/ ; Intramural NIH HHSUnited States/ ; R01-EY021214/EY/NEI NIH HHSUnited States/ ; DP1 MH100706/MH/NIMH NIH HHSUnited States/ ; P51-OD011092/OD/NIH HHSUnited States/ ; R01 DC012087/DC/NIDCD NIH HHSUnited States/ ; R01 HD059946/HD/NICHD NIH HHSUnited States/ ; Howard Hughes Medical InstituteUnited States/ ; R01-HD063276/HD/NICHD NIH HHSUnited States/ ; R01 DK097768/DK/NIDDK NIH HHSUnited States/ ; R01 EY021827/EY/NEI NIH HHSUnited States/ ; 5R01-DK097768/DK/NIDDK NIH HHSUnited States/ ; R01 NS24328/NS/NINDS NIH HHSUnited States/ ; R01-HD059946/HD/NICHD NIH HHSUnited States/ ; R01 HD057121/HD/NICHD NIH HHSUnited States/ ; R01 HD063276/HD/NICHD NIH HHSUnited States/ ; P30 CA014195/CA/NCI NIH HHSUnited States/
• Volume:
  86
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:89c944ab469a088b8c85925615b73b55ec7927cb5a994485dfaa42b5490211a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/31991/cdc_31991_DS1.pdf
• File Type:
  [PDF - 547.16 KB ]