NetworkPainter: dynamic intracellular pathway animation in Cytobank

Karr, Jonathan R; Guturu, Harendra; Chen, Edward Y; Blair, Stuart L; Irish, Jonathan M; Kotecha, Nikesh; Covert, Markus W

doi:10.1186/s12859-015-0602-4

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NetworkPainter: dynamic intracellular pathway animation in Cytobank

Published Date:

May 25 2015

Publisher's site:

http://dx.doi.org/10.1186/s12859-015-0602-4 New Site Icon

Source:

BMC Bioinformatics. 16(1).

[PDF-1.76 MB]

Details:

Alternative Title:

BMC Bioinformatics

Personal Author:

Karr, Jonathan R ; Guturu, Harendra ; Chen, Edward Y ; Blair, Stuart L ; Irish, Jonathan M ; ... More ▼

Description:

Background

High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data.

Results

We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and “paint” pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point.

Conclusion

NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data.

Electronic supplementary material

The online version of this article (doi:10.1186/s12859-015-0602-4) contains supplementary material, which is available to authorized users.

Subject:

[+]

Pubmed ID:

26003204

Pubmed Central ID:

PMC4491883

Document Type:

Journal Article

Funding:

1P50GM107615/GM/NIGMS NIH HHS/United States ; 5DP1LM01150-05/DP/NCCDPHP CDC HHS/United States ; CA125994-01A1/CA/NCI NIH HHS/United States ; CA143231/CA/NCI NIH HHS/United States ; K99 CA125994/CA/NCI NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	12859_2015_602_Fig1_HTML.gif	image/gif
	12859_2015_602_Fig1_HTML.jpg	image/jpeg
	12859_2015_602_Fig2_HTML.gif	image/gif
	12859_2015_602_Fig2_HTML.jpg	image/jpeg
	12859_2015_602_MOESM1_ESM.pdf	application/pdf
	12859_2015_Article_602.nxml	text/plain

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