Details:

Alternative Title:
Genet Med
Publisher's site:
http://dx.doi.org/10.1038/gim.2013.184
Personal Author:
Clyne, Mindy ; Schully, Sheri D. ; Dotson, W. David ; Douglas, Michael P. ; Gwinn, Marta ; ... More +
Clyne, Mindy ; Schully, Sheri D. ; Dotson, W. David ; Douglas, Michael P. ; Gwinn, Marta ; Kolor, Katherine ; Wulf, Anja ; Bowen, M. Scott ; Khoury, Muin J. Less -
Description:
The dizzying pace of genomic discoveries is leading to an increasing number of clinical applications. In this report, we provide a method for horizon scanning and 1 year data on translational research beyond bench to bedside to assess the validity, utility, implementation, and outcomes of such applications.|We compiled cross-sectional results of ongoing horizon scanning of translational genomic research, conducted between 16 May 2012 and 15 May 2013, based on a weekly, systematic query of PubMed. A set of 505 beyond bench to bedside articles were collected and classified, including 312 original research articles; 123 systematic and other reviews; 38 clinical guidelines, policies, and recommendations; and 32 articles describing tools, decision support, and educational materials.|Most articles (62%) addressed a specific genomic test or other health application; almost half of these (n = 180) were related to cancer. We estimate that these publications account for 0.5% of reported human genomics and genetics research during the same time.|These data provide baseline information to track the evolving knowledge base and gaps in genomic medicine. Continuous horizon scanning of the translational genomics literature is crucial for an evidence-based translation of genomics discoveries into improved health care and disease prevention.
Subject:
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Article Cross-Sectional Studies Decision Support Techniques Evidence-Based Medicine Genomic Medicine Genomics Humans Information Dissemination Meta-Analysis As Topic Public Health Surveillance Translational Medical Research Translational Research
Source:
Genet Med. 16(7):535-538.
Pubmed ID:
24406461
Pubmed Central ID:
PMC4079725
Document Type:
Journal Article
Funding:
Z99 CA999999/Intramural NIH HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4e0850030964132d587794721af2e3a2278d4eca2e84f7b8bb7c1f280b797b8f
Download URL:
https://stacks.cdc.gov/view/cdc/31957/cdc_31957_DS1.pdf
File Type:

Supporting Files

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  	NIHMS571299-supplement-Supplementary__Appendix__online_only_material__etc__.doc	doc
  	nihms571299.nxml	txt
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