Horizon Scanning for Translational Genomic Research Beyond Bench to Bedside

Details

• Alternative Title:
  Genet Med
• Personal Author:
  Clyne, Mindy ; Schully, Sheri D. ; Dotson, W. David ; Douglas, Michael P. ; Gwinn, Marta ; Kolor, Katherine ; Wulf, Anja ; Bowen, M. Scott ; Khoury, Muin J.
• Description:
  The dizzying pace of genomic discoveries is leading to an increasing number of clinical applications. In this report, we provide a method for horizon scanning and 1 year data on translational research beyond bench to bedside to assess the validity, utility, implementation, and outcomes of such applications.|We compiled cross-sectional results of ongoing horizon scanning of translational genomic research, conducted between 16 May 2012 and 15 May 2013, based on a weekly, systematic query of PubMed. A set of 505 beyond bench to bedside articles were collected and classified, including 312 original research articles; 123 systematic and other reviews; 38 clinical guidelines, policies, and recommendations; and 32 articles describing tools, decision support, and educational materials.|Most articles (62%) addressed a specific genomic test or other health application; almost half of these (n = 180) were related to cancer. We estimate that these publications account for 0.5% of reported human genomics and genetics research during the same time.|These data provide baseline information to track the evolving knowledge base and gaps in genomic medicine. Continuous horizon scanning of the translational genomics literature is crucial for an evidence-based translation of genomics discoveries into improved health care and disease prevention.
• Subjects:
  • Cross-Sectional Studies
  • Decision Support Techniques
  • Evidence-Based Medicine
  • Genomics
  • Humans
  • Information Dissemination
  • Meta-Analysis as Topic
  • Translational Medical Research
• Source:
  Genet Med. 16(7):535-538.
• Pubmed ID:
  24406461
• Pubmed Central ID:
  PMC4079725
• Document Type:
  Journal Article
• Funding:
  Z99 CA999999/Intramural NIH HHS/United States
• Volume:
  16
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/31957/cdc_31957_DS1.pdf
• File Type:
  [PDF - 99.33 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4e0850030964132d587794721af2e3a2278d4eca2e84f7b8bb7c1f280b797b8f