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Prenatal Diagnosis of Non-Syndromic Congenital Heart Defects
Filetype[PDF - 1.80 MB]


Details:
  • Corporate Authors:
    National Birth Defects Prevention Study
  • Pubmed ID:
    24222433
  • Pubmed Central ID:
    PMC4482476
  • Funding:
    CC999999/Intramural CDC HHS/United States
    FOA DD09-001/DD/NCBDD CDC HHS/United States
    PA 02081/PHS HHS/United States
    PA 96043/PHS HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Objectives

    Congenital heart defects (CHDs) occur in nearly 1% of live births. We sought to assess factors associated with prenatal CHD diagnosis in the National Birth Defects Prevention Study (NBDPS).

    Methods

    We analyzed data from mothers with CHD-affected pregnancies from 1998–2005. Prenatal CHD diagnosis was defined as affirmative responses to questions about abnormal prenatal ultrasounds and/or fetal echocardiography obtained during a structured telephone interview.

    Results

    Fifteen percent (1,097/7,299) of women with CHD-affected pregnancies (excluding recognized syndromes and single-gene disorders) reported receiving a prenatal CHD diagnosis. Prenatal CHD diagnosis was positively associated with advanced maternal age, family history of CHD, type 1 or type 2 diabetes, twin or higher order gestation, CHD complexity and presence of extracardiac defects. Prenatal CHD diagnosis was inversely associated with maternal Hispanic race/ethnicity, prepregnancy overweight or obesity, and pre-existing hypertension. Prenatal CHD diagnosis varied by time to NBDPS interview and NBDPS study site.

    Conclusions

    Further work is warranted to identify reasons for the observed variability in maternal reports of prenatal CHD diagnosis and the extent to which differences in health literacy or health system factors such as access to specialized prenatal care and/or fetal echocardiography may account for such variability.