I’m eating for two: parental dietary effects on offspring metabolism

Details

• Alternative Title:
  Cell
• Personal Author:
  Rando, Oliver J. ; Simmons, Rebecca A.
• Description:
  It has long been understood that the pathogenesis of complex diseases such as diabetes includes both genetic and environmental components. More recently, it has become clear that not only does an individual's environment influence their own metabolism, but in some cases, the environment experienced by their parents may also contribute to their risk of metabolic disease. Here, we review the evidence that parental diet influences metabolic phenotype in offspring in mammals and provide a current survey of our mechanistic understanding of these effects.
• Keywords:
  Animals Epigenesis, Genetic Feeding Behavior Female Genomic Imprinting Humans Maternal-Fetal Exchange Metabolic Diseases Nutritional Status Pregnancy
• Source:
  Cell. 161(1):93-105
• Pubmed ID:
  25815988
• Pubmed Central ID:
  PMC4465102
• Document Type:
  Journal Article
• Funding:
  R01DK55704/DK/NIDDK NIH HHSUnited States/ ; DP1ES02545/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK055704/DK/NIDDK NIH HHSUnited States/ ; R01ES023284/ES/NIEHS NIH HHSUnited States/ ; DP1 ES025458/ES/NIEHS NIH HHSUnited States/ ; R01 HD080224/HD/NICHD NIH HHSUnited States/ ; R01HD080224/HD/NICHD NIH HHSUnited States/ ; P30 ES013508/ES/NIEHS NIH HHSUnited States/ ; R01 ES023284/ES/NIEHS NIH HHSUnited States/ ; R01 DK062965/DK/NIDDK NIH HHSUnited States/ ; R01DK062965/DK/NIDDK NIH HHSUnited States/
• Volume:
  161
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ebb996a634472c29dd2fe46107e39014f4ea64139e32a05eb1e52afd4d1161d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/31609/cdc_31609_DS1.pdf
• File Type:
  [PDF - 777.92 KB ]