Details:

Alternative Title:
BJOG
Personal Author:
Grotegut, Chad A ; Kuklina, Elena V ; Anstrom, Kevin J ; Heine, R Phillips ; Callaghan, William M ; ... More +
Grotegut, Chad A ; Kuklina, Elena V ; Anstrom, Kevin J ; Heine, R Phillips ; Callaghan, William M ; Myers, Evan R ; James, Andra H Less -
Description:
Objective

Cardiomyopathy (CM) at delivery is increasing in prevalance. The objective of this study was to determine what medical conditions are attributable to this increasing prevalance.

Design

Population prevalence study from 2000 to 2009.

Setting

The Nationwide Inpatient Sample (NIS).

Methods

Pregnant women admitted for delivery were identified in the NIS for the years 2000-2009 and temporal trends in pre-existing medical conditions and medical and obstetric complications at delivery admissions were determined by linear regression. The change in the prevalence of CM among all pregnant women was compared to the change in the prevalance of CM among pregnant women without pre-existing conditions or complications.

Main Outcome Measures

Prevalence of cardiomyopathy.

Results

The prevalence of CM increased from 0.25 per 1000 deliveries in 2000 to 0.43 per 1000 deliveries in 2009 (p<0.0001). Women with chronic hypertension had increased odds of developing CM compared to women without chronic hypertension (odds ratio[OR] 13.2 [95% CI 12.5, 13.7]). The linear increase in chronic hypertension over the ten-year period was the single identified pre-existing medical condition that explained the increasing prevalence of CM at delivery (p=0.005 for the differences in the slopes for linear trend).

Conclusions

Pregnant women with chronic hypertenion are at an increased risk for CM at delivery and the increasing prevalence of chronic hypertension is an important factor associated with the increasing prevalence of CM at the time of delivery. Among women without chronic hypertension, the prevalence of CM at delivery did not change during the time period.


Subject:
[+]
Adolescent
Adult
Cardiomyopathies
Delivery, Obstetric
Female
Humans
Hypertension
Infant, Newborn
Odds Ratio
Pregnancy
Pregnancy Complications, Cardiovascular
Pregnancy Outcome
Prevalence

Source:
BJOG. 121(11):1386-1394
Pubmed ID:
24661593
Pubmed Central ID:
PMC4175993
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; K12 HD043446/HD/NICHD NIH HHS/United States ; K12-HD-043446/HD/NICHD NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; K12 HD043446/HD/NICHD NIH HHS/United States ; K12-HD-043446/HD/NICHD NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ec94c94ac5c3247344dcad49480320f1c0707c9356fc674223afcd072b8763f0
File Type:

Supporting Files

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  	nihms-579531-f0002.jpg	jpeg
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  	NIHMS579531-supplement-Supp_Fig_S1-S4.pdf	pdf
  	NIHMS579531-supplement-Supp_Table_S1-S3.pdf	pdf

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