24661593

PMC4175993

Objective

Cardiomyopathy (CM) at delivery is increasing in prevalance. The objective of this study was to determine what medical conditions are attributable to this increasing prevalance.

Design

Population prevalence study from 2000 to 2009.

Setting

The Nationwide Inpatient Sample (NIS).

Methods

Pregnant women admitted for delivery were identified in the NIS for the years 2000-2009 and temporal trends in pre-existing medical conditions and medical and obstetric complications at delivery admissions were determined by linear regression. The change in the prevalence of CM among all pregnant women was compared to the change in the prevalance of CM among pregnant women without pre-existing conditions or complications.

Main Outcome Measures

Prevalence of cardiomyopathy.

Results

The prevalence of CM increased from 0.25 per 1000 deliveries in 2000 to 0.43 per 1000 deliveries in 2009 (p<0.0001). Women with chronic hypertension had increased odds of developing CM compared to women without chronic hypertension (odds ratio[OR] 13.2 [95% CI 12.5, 13.7]). The linear increase in chronic hypertension over the ten-year period was the single identified pre-existing medical condition that explained the increasing prevalence of CM at delivery (p=0.005 for the differences in the slopes for linear trend).

Conclusions

Pregnant women with chronic hypertenion are at an increased risk for CM at delivery and the increasing prevalence of chronic hypertension is an important factor associated with the increasing prevalence of CM at the time of delivery. Among women without chronic hypertension, the prevalence of CM at delivery did not change during the time period.

CDC Public Access

CC999999/Intramural CDC HHS/United States
K12 HD043446/HD/NICHD NIH HHS/United States
K12-HD-043446/HD/NICHD NIH HHS/United States