Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Portugues, Ruben; Feierstein, Claudia E.; Engert, Florian; Orger, Michael B.

doi:10.1016/j.neuron.2014.01.019

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Published Date:

Mar 19 2014

Publisher's site:

http://dx.doi.org/10.1016/j.neuron.2014.01.019 New Site Icon

Source:

Neuron. 2014; 81(6):1328-1343.

[PDF-2.10 MB]

Details:

Personal Authors:

Portugues, Ruben ; Feierstein, Claudia E. ; Engert, Florian ; Orger, Michael B. ;

Keywords:

[+]

Pubmed ID:

24656252

Pubmed Central ID:

PMC4448760

Description:

Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP1 NS082121/NS/NINDS NIH HHS/United States
DP1-NS082121/DP/NCCDPHP CDC HHS/United States
R01 DA030304/DA/NIDA NIH HHS/United States
R01-DA030304/DA/NIDA NIH HHS/United States
U01 NS090449/NS/NINDS NIH HHS/United States

Supporting Files:

	NIHMS577899-supplement-09.mov	video/quicktime
	NIHMS577899-supplement-10.mov	video/quicktime
	NIHMS577899-supplement-11.mov	video/quicktime
	nihms577899.nxml	application/octet-stream
	nihms577899f1.gif	image/gif
	nihms577899f1.jpg	image/jpeg
	nihms577899f2.gif	image/gif
	nihms577899f2.jpg	image/jpeg
	nihms577899f3.gif	image/gif
	nihms577899f3.jpg	image/jpeg
	NIHMS577899-supplement-01.pdf	application/pdf
	nihms577899f4.gif	image/gif
	nihms577899f4.jpg	image/jpeg
	nihms577899f5.gif	image/gif
	nihms577899f5.jpg	image/jpeg
	nihms577899f6.gif	image/gif
	nihms577899f6.jpg	image/jpeg
	nihms577899f7.gif	image/gif
	nihms577899f7.jpg	image/jpeg
	nihms577899f8.gif	image/gif
	nihms577899f8.jpg	image/jpeg
	NIHMS577899-supplement-02.mov	video/quicktime
	nihms577899f9.gif	image/gif
	nihms577899f9.jpg	image/jpeg
	NIHMS577899-supplement-03.mov	video/quicktime
	NIHMS577899-supplement-04.mov	video/quicktime
	NIHMS577899-supplement-05.mov	video/quicktime
	NIHMS577899-supplement-06.mov	video/quicktime
	NIHMS577899-supplement-07.mov	video/quicktime
	NIHMS577899-supplement-08.mov	video/quicktime

No Related Documents.

You May Also Like:

Whole-brain activity mapping onto a zebrafish brain atlas

Personal Author:

Randlett, Owen; Wee, Caroline L.; Naumann, Eva A.; Nnaemeka, Onyeka; Schoppik, David; Fitzgerald, James E.; Portugues, Ruben; Lacoste, Alix M.B.; Riegler, Clemens; Engert, Florian; Schier, Alexander F.;

Published:

Nov 2015

Source:

Nat Methods. 12(11):1039-1046.

Description:

In order to localize the neural circuits involved in generating behaviors, it is necessary to assign activity onto anatomical maps of the nervous system. Using brain registration across hundreds of larval zebrafish, we have built an expandable open-s...

File Type:

[PDF - 2.52 MB]
Neural control and modulation of swimming speed in the larval zebrafish

Personal Author:

Severi, Kristen E.; Portugues, Ruben; Marques, João C.; O'Malley, Donald M.; Orger, Michael B.; Engert, Florian;

Published:

Jul 24 2014

Source:

Neuron. 2014; 83(3):692-707.

Description:

Vertebrate locomotion at different speeds is driven by descending excitatory connections to central pattern generators in the spinal cord. To investigate how these inputs determine locomotor kinematics, we used whole-field visual motion to drive zebr...

File Type:

[PDF - 1.73 MB]
Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

Personal Author:

Dunn, Timothy W; Mu, Yu; Narayan, Sujatha; Randlett, Owen; Naumann, Eva A; Yang, Chao-Tsung; Schier, Alexander F; Freeman, Jeremy; Engert, Florian; Ahrens, Misha B;

Published:

Mar 22 2016

Source:

eLife. 2016; 5.

Description:

In the absence of salient sensory cues to guide behavior, animals must still execute sequences of motor actions in order to forage and explore. How such successive motor actions are coordinated to form global locomotion trajectories is unknown. We ma...

File Type:

[PDF - 4.98 MB]
Large-scale imaging in small brains

Personal Author:

Ahrens, Misha B.; Engert, Florian;

Published:

Jan 28 2015

Source:

Curr Opin Neurobiol. 32:78-86.

Description:

The dense connectivity in the brain means that one neuron's activity can influence many others. To observe this interconnected system comprehensively, an aspiration within neuroscience is to record from as many neurons as possible at the same ti...

File Type:

[PDF - 319.83 KB]
Structured variability in Purkinje cell activity during locomotion

Personal Author:

Sauerbrei, Britton A.; Lubenov, Evgueniy V.; Siapas, Athanassios G.;

Published:

Aug 19 2015

Source:

Neuron. 87(4):840-852.

Description:

The cerebellum is a prominent vertebrate brain structure that is critically involved in sensorimotor function. During locomotion, cerebellar Purkinje cells are rhythmically active, shaping descending signals and coordinating commands from higher brai...

File Type:

[PDF - 2.88 MB]