Details:

Alternative Title:
Neuron
Publisher's site:
http://dx.doi.org/10.1016/j.neuron.2014.01.019
Personal Author:
Portugues, Ruben ; Feierstein, Claudia E. ; Engert, Florian ; Orger, Michael B. ;
Portugues, Ruben ; Feierstein, Claudia E. ; Engert, Florian ; Orger, Michael B. ; Less -
Description:
Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.
Subject:
[+]
Animals
Article
Behavior, Animal
Brain
Brain Mapping
Nerve Net
Neuroimaging
Neurons
Zebrafish

Source:
Neuron. 2014 ; 81(6):1328-1343.;
Pubmed ID:
24656252
Pubmed Central ID:
PMC4448760
Document Type:
Journal Article ;
Funding:
DP1 NS082121/NS/NINDS NIH HHS/United States ; DP1-NS082121/DP/NCCDPHP CDC HHS/United States ; R01 DA030304/DA/NIDA NIH HHS/United States ; R01-DA030304/DA/NIDA NIH HHS/United States ; U01 NS090449/NS/NINDS NIH HHS/United States ;
DP1 NS082121/NS/NINDS NIH HHS/United States ; DP1-NS082121/DP/NCCDPHP CDC HHS/United States ; R01 DA030304/DA/NIDA NIH HHS/United States ; R01-DA030304/DA/NIDA NIH HHS/United States ; U01 NS090449/NS/NINDS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9df83e76e92d3f02da0d63c075422d3a502cd03f04df5d94b5d2a7804e804b32
File Type:

Supporting Files

• 	NIHMS577899-supplement-09.mov	mov
  	NIHMS577899-supplement-10.mov	mov
  	NIHMS577899-supplement-11.mov	mov
  	nihms577899.nxml	bin
  	nihms577899f1.gif	gif
  	nihms577899f1.jpg	jpeg
  	nihms577899f2.gif	gif
  	nihms577899f2.jpg	jpeg
  	nihms577899f3.gif	gif
  	nihms577899f3.jpg	jpeg
  	NIHMS577899-supplement-01.pdf	pdf
  	nihms577899f4.gif	gif
  	nihms577899f4.jpg	jpeg
  	nihms577899f5.gif	gif
  	nihms577899f5.jpg	jpeg
  	nihms577899f6.gif	gif
  	nihms577899f6.jpg	jpeg
  	nihms577899f7.gif	gif
  	nihms577899f7.jpg	jpeg
  	nihms577899f8.gif	gif
  	nihms577899f8.jpg	jpeg
  	NIHMS577899-supplement-02.mov	mov
  	nihms577899f9.gif	gif
  	nihms577899f9.jpg	jpeg
  	NIHMS577899-supplement-03.mov	mov
  	NIHMS577899-supplement-04.mov	mov
  	NIHMS577899-supplement-05.mov	mov
  	NIHMS577899-supplement-06.mov	mov
  	NIHMS577899-supplement-07.mov	mov
  	NIHMS577899-supplement-08.mov	mov

More +