Welcome to CDC stacks | Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior - 31327 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior
Filetype[PDF-2.10 MB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:
    Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.

  • Document Type:
  • Collection(s):
  • Funding:
    DP1 NS082121/NS/NINDS NIH HHS/United States
    DP1-NS082121/DP/NCCDPHP CDC HHS/United States
    R01 DA030304/DA/NIDA NIH HHS/United States
    R01-DA030304/DA/NIDA NIH HHS/United States
    U01 NS090449/NS/NINDS NIH HHS/United States
No Related Documents.
You May Also Like: