Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Portugues, Ruben; Feierstein, Claudia E.; Engert, Florian; Orger, Michael B.

doi:10.1016/j.neuron.2014.01.019

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Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Published Date:

Mar 19 2014

Publisher's site:

http://dx.doi.org/10.1016/j.neuron.2014.01.019 New Site Icon

Source:

Neuron. 2014; 81(6):1328-1343.

[PDF-2.10 MB]

Details:

Personal Authors:

Portugues, Ruben ; Feierstein, Claudia E. ; Engert, Florian ; Orger, Michael B. ;

Keywords:

[+]

Pubmed ID:

24656252

Pubmed Central ID:

PMC4448760

Description:

Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP1 NS082121/NS/NINDS NIH HHS/United States
DP1-NS082121/DP/NCCDPHP CDC HHS/United States
R01 DA030304/DA/NIDA NIH HHS/United States
R01-DA030304/DA/NIDA NIH HHS/United States
U01 NS090449/NS/NINDS NIH HHS/United States

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