Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12075
Personal Author:
Caspers, Kristin M. ; Romitti, Paul A. ; Lin, Shao ; Olney, Richard S. ; Holmes, Lewis B. ; ... More +
Caspers, Kristin M. ; Romitti, Paul A. ; Lin, Shao ; Olney, Richard S. ; Holmes, Lewis B. ; Werler, Martha M. Less -
Description:
Background

Congenital limb deficiencies (LD)s are characterised by the failure or disruption in formation of limbs or digits. Epidemiological research on maternal exposure to cigarette smoke and LDs is inconclusive.

Methods

Data from the National Birth Defects Prevention Study were used to examine LDs and maternal exposure to active or passive cigarette smoke. Mothers of LD case (n = 906) and unaffected control (n = 8352) pregnancies from October 1997 through December 2007 reported on exposure type and quantity. Logistic regression was used to estimate adjusted odds ratio (OR) and 95% confidence interval [95% CI]; interactions with folic acid (FA) intake were tested.

Results

For any LD, ORs were elevated for active (1.24 [95% CI 1.01, 1.53]), passive (home) (1.28 [95% CI 1.03, 1.59]), and ‘active and passive’ (1.34 [95% CI 1.05, 1.70]) exposures. The ORs for longitudinal LDs were elevated for passive (home) (1.62 [95% CI 1.14, 2.31]) and ‘active and passive’ (1.62 [95% CI 1.09, 2.41]) exposures. The OR for pre-axial LDs were elevated for any (1.39 [95% CI 1.01, 1.90]), active (1.53 [95% CI 1.03, 2.29]), passive (home) (1.82 [95% CI 1.23, 2.69]), and ‘active and passive’ (1.87 [95% CI 1.20, 2.92]) exposures. For lower limbs, ORs were elevated for passive (home) (1.44 [95% CI 1.01, 2.04]) and smoking 15 or more cigarettes/day (2.25 [95% CI 1.27, 3.97]). Interactions showed that ORs for any passive smoke exposure were 0.43 and 0.59 higher in the absence of FA intake for any and terminal transverse LDs.

Conclusions

Maternal active smoking and exposure to passive cigarette smoke emerged as a potential teratogen that affects limb and digit formation. FA was not found to mitigate the impact.


Subject:
[+]
Adult
Case-Control Studies
Female
Humans
Infant, Newborn
Limb Deformities, Congenital
Logistic Models
Male
Maternal Exposure
Odds Ratio
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Smoking
Tobacco Smoke Pollution
Young Adult

Source:
Paediatr Perinat Epidemiol. 2013; 27(6):509-520.
Document Type:
Journal Article
Funding:
AVU3/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States ; U01DD000492/DD/NCBDD CDC HHS/United States
AVU3/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States ; U01DD000492/DD/NCBDD CDC HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:98e6e0fbfc4306e646d3726962801e5b372a2bba4e3d5a53cea667ad6af932f3
File Type:

Supporting Files

• nihms692531.nxml

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