Genetic polymorphisms and susceptibility to lung disease

Details

• Alternative Title:
  J Negat Results Biomed
• Personal Author:
  Lee, Pauline L ; West, Carol ; Crain, Karen ; Wang, Lei
• Description:
  Susceptibility to infection by bacterium such as Bacillus anthracis has a genetic basis in mice and may also have a genetic basis in humans. In the limited human cases of inhalation anthrax, studies suggest that not all individuals exposed to anthrax spores were infected, but rather, individuals with underlying lung disease, particularly asthma, sarcoidosis and tuberculosis, might be more susceptible. In this study, we determined if polymorphisms in genes important in innate immunity are associated with increased susceptibility to infectious and non-infectious lung diseases, particularly tuberculosis and sarcoidosis, respectively, and therefore might be a risk factor for inhalation anthrax. Examination of 45 non-synonymous polymorphisms in ten genes: p47phox (NCF1), p67phox (NCF2), p40phox (NCF4), p22phox (CYBA), gp91phox (CYBB), DUOX1, DUOX2, TLR2, TLR9 and alpha 1-antitrypsin (AAT) in a cohort of 95 lung disease individuals and 95 control individuals did not show an association of these polymorphisms with increased susceptibility to lung disease.
• Subjects:
  • Cohort Studies
  • White People
  • Flavoproteins
  • Genetic Predisposition to Disease
  • Humans
  • Lung Diseases
  • Membrane Glycoproteins
  • Mycobacterium Infections, Nontuberculous
  • NADPH Oxidase
  • Phosphoproteins
  More +
• Source:
  J Negat Results Biomed. 2006; 5:5.
• Document Type:
  Journal Article
• Funding:
  5PO1 CI000095/CI/NCPDCID CDC HHS/United States
• Place as Subject:
  California
• Volume:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/31255/cdc_31255_DS1.pdf
• File Type:
  [PDF - 308.33 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:10905e632651802e37bb78f1c3e366bb5ecc16e9e449da420c3829cfbd442389