Genetic polymorphisms and susceptibility to lung disease

Lee, Pauline L; West, Carol; Crain, Karen; Wang, Lei

doi:10.1186/1477-5751-5-5

i

Genetic polymorphisms and susceptibility to lung disease

Supporting Files

Apr 11 2006
By Lee, Pauline L ; West, Carol ; Crain, Karen ; ...

File Language:

English

Details

Alternative Title:

J Negat Results Biomed
Personal Author:

Lee, Pauline L ; West, Carol ; Crain, Karen ; Wang, Lei
Description:

Susceptibility to infection by bacterium such as Bacillus anthracis has a genetic basis in mice and may also have a genetic basis in humans. In the limited human cases of inhalation anthrax, studies suggest that not all individuals exposed to anthrax spores were infected, but rather, individuals with underlying lung disease, particularly asthma, sarcoidosis and tuberculosis, might be more susceptible. In this study, we determined if polymorphisms in genes important in innate immunity are associated with increased susceptibility to infectious and non-infectious lung diseases, particularly tuberculosis and sarcoidosis, respectively, and therefore might be a risk factor for inhalation anthrax. Examination of 45 non-synonymous polymorphisms in ten genes: p47phox (NCF1), p67phox (NCF2), p40phox (NCF4), p22phox (CYBA), gp91phox (CYBB), DUOX1, DUOX2, TLR2, TLR9 and alpha 1-antitrypsin (AAT) in a cohort of 95 lung disease individuals and 95 control individuals did not show an association of these polymorphisms with increased susceptibility to lung disease.
Subjects:

Alpha 1-Antitrypsin Cohort Studies Flavoproteins Genetic Predisposition To Disease Humans Lung Diseases Membrane Glycoproteins Mycobacterium Infections, Nontuberculous NADPH Oxidase Phosphoproteins Pneumonia Polymorphism, Single Nucleotide Sarcoidosis, Pulmonary Toll-Like Receptor 2 Toll-Like Receptor 9 Tuberculosis, Pulmonary White People
Source:

J Negat Results Biomed. 2006; 5:5.
Document Type:

Journal Article
Funding:

5PO1 CI000095/CI/NCPDCID CDC HHS/United States
Place as Subject:

California
Volume:

5
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:10905e632651802e37bb78f1c3e366bb5ecc16e9e449da420c3829cfbd442389
Download URL:

https://stacks.cdc.gov/view/cdc/31255/cdc_31255_DS1.pdf
File Type:

[PDF - 308.33 KB ]

1477-5751-5-5.nxml

Download txt
license.txt

Download txt

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.