Genetic polymorphisms and susceptibility to lung disease
Published Date:Apr 11 2006
Source:J Negat Results Biomed. 2006; 5:5.
European Continental Ancestry Group
Genetic Predisposition To Disease
Mycobacterium Infections, Nontuberculous
Polymorphism, Single Nucleotide
Toll-Like Receptor 2
Toll-Like Receptor 9
Funding:5PO1 CI000095/CI/NCPDCID CDC HHS/United States
Description:Susceptibility to infection by bacterium such as Bacillus anthracis has a genetic basis in mice and may also have a genetic basis in humans. In the limited human cases of inhalation anthrax, studies suggest that not all individuals exposed to anthrax spores were infected, but rather, individuals with underlying lung disease, particularly asthma, sarcoidosis and tuberculosis, might be more susceptible. In this study, we determined if polymorphisms in genes important in innate immunity are associated with increased susceptibility to infectious and non-infectious lung diseases, particularly tuberculosis and sarcoidosis, respectively, and therefore might be a risk factor for inhalation anthrax. Examination of 45 non-synonymous polymorphisms in ten genes: p47phox (NCF1), p67phox (NCF2), p40phox (NCF4), p22phox (CYBA), gp91phox (CYBB), DUOX1, DUOX2, TLR2, TLR9 and alpha 1-antitrypsin (AAT) in a cohort of 95 lung disease individuals and 95 control individuals did not show an association of these polymorphisms with increased susceptibility to lung disease.
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