Details:

Alternative Title:
J Child Neurol
Publisher's site:
http://dx.doi.org/10.1177/0883073814558120
Personal Author:
Kim, Sunkyung ; Campbell, Kimberly A. ; Fox, Deborah J. ; Matthews, Dennis J. ; Valdez, Rodolfo ;
Kim, Sunkyung ; Campbell, Kimberly A. ; Fox, Deborah J. ; Matthews, Dennis J. ; Valdez, Rodolfo ; Less -
Corporate Authors:
MD STAR ;
Description:
This population-based study examines the association between corticosteroid treatment and time to loss of ambulation, stratifying by treatment duration (short: 0.25-3 years, long: >3 years), among 477 Duchenne muscular dystrophy cases identified by the Muscular Dystrophy Surveillance Tracking and Research Network (MDSTARnet). Those cases who received short-term corticosteroid treatment had a time to loss of ambulation that was 0.8 years shorter (t test) and an annual risk of losing ambulation 77% higher than the untreated (Cox regression). Conversely, cases who received long-term corticosteroid treatment had a time to loss of ambulation that was 2 years longer and an annual risk of losing ambulation 82% lower than the untreated, up to age 11 years; after which the risks were not statistically different. The relationship of corticosteroids and time to loss of ambulation is more complex than depicted by previous studies limited to treatment responders or subjects who lost ambulation during study follow-up.
Subject:
[+]
Adrenal Cortex Hormones
Age Of Onset
Child
Disease Progression
Follow-Up Studies
Humans
Longitudinal Studies
Male
Muscular Dystrophy, Duchenne
Neuromuscular Agents
Prednisone
Pregnenediones
Proportional Hazards Models
Time Factors
Walking

Source:
J Child Neurol. 30(10):1275-1280.
Pubmed ID:
25414237
Pubmed Central ID:
PMC4439376
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; U01 DD000191/DD/NCBDD CDC HHS/United States ; 5 U01 DD000191/DD/NCBDD CDC HHS/United States ;
CC999999/Intramural CDC HHS/United States ; U01 DD000191/DD/NCBDD CDC HHS/United States ; 5 U01 DD000191/DD/NCBDD CDC HHS/United States ; Less -
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a453015896a09a8c39c366979c55aba299c21c7cbad16301a7e2416b307a5e65
File Type:

Supporting Files

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