Reported breast symptoms in the National Breast and Cervical Cancer Early Detection Program

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Ryerson, A. Blythe ; Miller, Jacqueline ; Eheman, Christie R.
• Description:
  Purpose
  
  The frequency and types of breast symptoms reported by women in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) have never been characterized. This study aims to establish the frequency of reported symptoms and the diagnostic outcomes associated with reported symptoms.
  
  Methods
  
  We examined the frequency of symptoms reported prior to mammography using medical record abstraction data from women in the NBCCEDP. We also calculated adjusted odds ratios (aOR) of having an abnormal mammogram, an abnormal clinical breast examination (CBE), or a final diagnosis of breast cancer by symptoms, compared to asymptomatic women.
  
  Results
  
  In our sample of women, 10.3% reported at least one symptom. Women with symptoms were younger and more likely to be non-Hispanic white. Among those reporting symptoms, breast lump (31.7%) and pain or tenderness (49.3%) was most common. A relatively low proportion of women with symptoms were diagnosed with in situ (0.9%) or invasive breast cancer (4.3%). However, a self-reported breast lump (aOR: 13.7; 95% confidence interval [CI]: 7.8 – 24.1), inflammation or changes to the skin/nipple (aOR: 27.8; 95% CI: 8.7 – 88.8) and other or unspecified symptoms (aOR: 3.4; 95% CI: 2.1 – 7.5) were associated with an increased risk of invasive breast cancer.
  
  Conclusions
  
  Although the prevalence of breast cancer among women reporting symptoms is relatively low, knowing which symptoms carry the highest breast cancer risk is important to assist in appropriate diagnostic workup.
  
  
• Subjects:
  Adult Age Factors Article Breast Cancer Breast Neoplasms Breast Symptoms Early Detection Of Cancer Female Humans Mammography Mass Screening Middle Aged Screening Symptom Assessment Young Adult

  More +
• Source:
  Cancer Causes Control. 26(5):733-740.
• Pubmed ID:
  25754109
• Pubmed Central ID:
  PMC4431920
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  26
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:944535f6d46de9cdfae71c3c94f1ad9d4b25b0136f4cbdb0ce1c4a9de576a1c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/31123/cdc_31123_DS1.pdf
• File Type:
  [PDF - 384.46 KB ]