i
Using Non-Enzymatic Chemistry to Influence Microbial Metabolism
-
4 2015
-
Source: Curr Opin Chem Biol. 2014; 25:71-79
[PDF-1.11 MB]
Details:
-
Alternative Title:Curr Opin Chem Biol
-
Personal Author:
-
Description:The structural manipulation of small molecule metabolites occurs in all organisms and plays a fundamental role in essentially all biological processes. Despite an increasing interest in developing new, non-enzymatic chemical reactions capable of functioning in the presence of living organisms, the ability of such transformations to interface with cellular metabolism and influence biological function is a comparatively underexplored area of research. This review will discuss efforts to combine non-enzymatic chemistry with microbial metabolism. We will highlight recent and historical uses of non-biological reactions to study microbial growth and function, the use of non-enzymatic transformations to rescue auxotrophic microorganisms, and the combination of engineered microbial metabolism and biocompatible chemical reactions for organic synthesis.
-
Subjects:
-
Source:
-
Pubmed ID:25579453
-
Pubmed Central ID:PMC4380663
-
Document Type:
-
Funding:
-
Volume:25
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
