Using Non-Enzymatic Chemistry to Influence Microbial Metabolism

Details

• Alternative Title:
  Curr Opin Chem Biol
• Personal Author:
  Wallace, Stephen ; Schultz, Erica E. ; Balskus, Emily P.
• Description:
  The structural manipulation of small molecule metabolites occurs in all organisms and plays a fundamental role in essentially all biological processes. Despite an increasing interest in developing new, non-enzymatic chemical reactions capable of functioning in the presence of living organisms, the ability of such transformations to interface with cellular metabolism and influence biological function is a comparatively underexplored area of research. This review will discuss efforts to combine non-enzymatic chemistry with microbial metabolism. We will highlight recent and historical uses of non-biological reactions to study microbial growth and function, the use of non-enzymatic transformations to rescue auxotrophic microorganisms, and the combination of engineered microbial metabolism and biocompatible chemical reactions for organic synthesis.
• Subjects:
  Ecosystem Metabolism Microbiology Small Molecule Libraries
• Source:
  Curr Opin Chem Biol. 2014; 25:71-79
• Pubmed ID:
  25579453
• Pubmed Central ID:
  PMC4380663
• Document Type:
  Journal Article
• Funding:
  DP2 GM105434/GM/NIGMS NIH HHSUnited States/ ; DP2 GM105434/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  25
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3c59fbb9fef93459a808cfcf28de22644edb95ff6f3098277110ebfda1123d83
• Download URL:
  https://stacks.cdc.gov/view/cdc/31121/cdc_31121_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]