Vitamin D receptor Fok1 polymorphism and blood lead concentration in children.

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Haynes, Erin N ; Kalkwarf, Heidi J ; Hornung, Richard ; Wenstrup, Richard ; Dietrich, Kim ; Lanphear, Bruce P
• Description:
  Variation in blood lead concentration is caused by a complex interaction of environmental, social, nutritional, and genetic factors. We evaluated the association between blood lead concentration and a vitamin D receptor (VDR) gene polymorphism. Environmental samples and blood were analyzed for lead, nutritional and behavioral factors were assessed, and VDR -Fok1 genotype was determined in 245 children. We found a significant interaction between floor dust lead and genotype on blood lead concentration. For every 1 microg/ft(2) increase in floor dust, children with VDR -FF genotype had a 1.1% increase in blood lead [95% confidence interval (CI), 0.69-1.5], VDR -Ff, 0.53% increase (95% CI, 0.1-0.92), and VDR -ff, 3.8% increase (95% CI, 1.2-6.3); however, at floor dust levels < 10 microg/ft(2), children with VDR -ff had the lowest blood lead concentrations. These data suggest that VDR -Fok1 is an effect modifier of the relationship of floor dust lead exposure and blood lead concentration.
• Subjects:
  Child, Preschool Cohort Studies Dust Environmental Exposure Female Genetic Predisposition To Disease Genotype Humans Infant Lead Lead Poisoning Male Polymerase Chain Reaction Polymorphism, Genetic Receptors, Calcitriol

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• Source:
  Environ Health Perspect. 111(13):1665-1669.
• Document Type:
  Journal Article
• Funding:
  5 T32 ES10957-02/ES/NIEHS NIH HHS/United States ; ES006096/ES/NIEHS NIH HHS/United States ; ES11261/ES/NIEHS NIH HHS/United States ; R01-ES08338/ES/NIEHS NIH HHS/United States ; U67/CCU210773/CC/ODCDC CDC HHS/United States
• Volume:
  111
• Issue:
  13
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:29492f73fca4d115bc7172d7d5d5e72ebc60cd1e04e13cca81c63e27b8b00d58
• Download URL:
  https://stacks.cdc.gov/view/cdc/30997/cdc_30997_DS1.pdf
• File Type:
  [PDF - 146.48 KB ]